3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-tosyl-1H-pyrazole CAS 477712-64-4
| CAS No. | 477712-64-4 |
| Molecular Formula | C23H18ClFN2O3S |
| Molecular Weight | 456.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-tosyl-1H-pyrazole (CAS 477712-64-4), a certified reference material (molecular formula C23H18ClFN2O3S, MW 456.92 g/mol) for analytical method development and quality control.
The molecular framework of 3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-tosyl-1H-pyrazole (C23H18ClFN2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-tosyl-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H18ClFN2O3S |
| Molecular Weight | 456.92 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1-(4-methylbenzenesulfonyl)-1H-pyrazole (CAS 477710-94-4)
- 4-Chloro-2-(4-(N,N-diethylsulfamoyl)phenyl)quinoline-6-sulfonyl fluoride (CAS 31242-12-3)
- 2-Chloro-N'-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridine-6-carbonyl)benzenesulfonohydrazide (CAS 866137-85-1)
- 2-((7-Chloro-3-(furan-2-ylmethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(1-cyanocyclohexyl)acetamide (CAS 852411-17-7)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-N-(3-methoxybenzyl)-1-methyl-1H-imidazole-5-carboxamide (CAS 339278-17-0)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-5-[(E)-2-[(4-fluorophenyl)amino]ethenyl]-1,2-thiazole-4-carbonitrile (CAS 338413-05-1)
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-N-(3,5-dimethylphenyl)benzenesulfonamide (CAS 338775-29-4)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(2,3-dimethylphenyl)benzene-1-sulfonamide (CAS 338775-36-3)
Recommended Standards
- 1-(4-Chlorobenzenesulfonyl)-3-[1-({2-fluoro-[1,1'-biphenyl]-4-yl}oxy)ethyl]-1H-pyrazole (CAS 477711-04-9)
- (2E)-2-(Benzenesulfonyl)-3-{2-[(4-chlorophenyl)sulfanyl]-5-nitrophenyl}prop-2-enenitrile (CAS 1025642-11-8)
- 4-(Benzo[d]thiazol-2-ylthio)-3-nitrobenzyl 2-chlorobenzoate (CAS 320424-23-5)
- Dapagliflozin Impurity 201 (CAS CATO-C4X-1138201)
- 2-Methyl-4-[(2-methylpentyl)oxy]aniline (CAS 946785-92-8)
- 2-(3-Bromo-4-methoxyphenyl)-1H-imidazole (CAS 326809-10-3)
- 2-[5-(piperidin-4-yl)-1h-pyrazol-1-yl]ethan-1-ol (CAS 1251923-87-1)
- Aceclofenac tert-Butyl Ester (CAS 139272-68-7)
- 1,3,6-Trimethyl-5-nitropyrimidine-2,4(1H,3H)-dione (CAS 55326-07-3)
- Ethyl 4-(2-hydroxyphenyl)butanoate (CAS 20921-17-9)
- 3-(4-Chlorophenyl)glutaric-d4 Anhydride (CAS 1189700-43-3)
- 5-Amino-4',5'-dihydro-2H,3'H-spiro[benzo[b]thiophene-3,2'-furan] 1,1-dioxide (CAS 2693402-48-9)
- 2-(4-Amino-1h-pyrazol-1-yl)-N-ethylacetamide (CAS 1152939-93-9)
- Semaglutide (CAS 910463-68-2（free base）)
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