3-[(2-Chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)benzaldehyde CAS 477846-07-4

Purity 97%+In StockPharmaceutical Standards
CAS No.477846-07-4
Molecular FormulaC20H22ClFO3
Molecular Weight364.84 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-[(2-Chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)benzaldehyde CAS 477846-07-4 chemical structure

Description

The occurrence of 3-[(2-Chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)benzaldehyde is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3-[(2-Chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)benzaldehyde (CAS 477846-07-4), molecular formula C20H22ClFO3 and molecular weight 364.84 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 3-[(2-Chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)benzaldehyde is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 364.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC20H22ClFO3
Molecular Weight364.84 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentF/Cl-containing

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