5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1,3,4-thiadiazole-2(3H)-thione CAS 477846-12-1
| CAS No. | 477846-12-1 |
| Molecular Formula | C8H3ClF3N3S3 |
| Molecular Weight | 329.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1,3,4-thiadiazole-2(3H)-thione (C8H3ClF3N3S3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1,3,4-thiadiazole-2(3H)-thione (CAS 477846-12-1), molecular formula C8H3ClF3N3S3 and molecular weight 329.77 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1,3,4-thiadiazole-2(3H)-thione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF3N3S3 |
| Molecular Weight | 329.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 3 |
Related Chloro Standards
- 3-Chloro-2-{[(2E)-3-phenylprop-2-en-1-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 321430-93-7)
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Recommended Standards
- 2-(Bicyclo[2.2.1]heptan-2-yl)-N-(3-chloro-4-(difluoromethoxy)phenyl)acetamide (CAS 1005126-81-7)
- Methyl 1-(2-chlorobenzyl)-3,6-dimethyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011359-95-7)
- Furosemide Amide Impurity (CAS 4793-47-9)
- Methyl 1-(4-chlorobenzyl)-3,6-dimethyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011370-91-4)
- 2-((6-Oxo-1,6-dihydropyrimidin-2-yl)thio)acetic acid (CAS 20650-30-0)
- 4-Amino-3-(dimethylphosphoryl)benzoic acid (CAS 2287302-62-7)
- 4,7-Dichloro-5-fluoro-1H-indole-2-carboxylic acid (CAS 2755782-68-2)
- 6-Ethoxy-N4-(2-fluoroethyl)pyrimidine-4,5-diamine (CAS 326831-57-6)
- Ethyl 2-{[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]amino}-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate (CAS 861211-28-1)
- 4-(methylamino)piperidine-4-carbonitrile (CAS 1251212-32-4)
- 5-Cyclopropoxy-N-methyl-3-(methylamino)picolinamide (CAS 1243465-03-3)
- 6-Chloro-N-((tetrahydro-2H-pyran-4-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 1263374-36-2)
- 6-(tert-Butyl)-5-cyclopropoxypyridin-3-amine (CAS 1243440-11-0)
- Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide trifluoroacetate salt (CAS 683750-83-6)
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