3-(4-Chlorobenzyl)-4-hydroxy-1-(4-methoxyphenyl)pyridin-2(1H)-one CAS 477846-49-4

Purity 97%+In StockPharmaceutical Standards
CAS No.477846-49-4
Molecular FormulaC19H16ClNO3
Molecular Weight341.79 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-(4-Chlorobenzyl)-4-hydroxy-1-(4-methoxyphenyl)pyridin-2(1H)-one CAS 477846-49-4 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

3-(4-Chlorobenzyl)-4-hydroxy-1-(4-methoxyphenyl)pyridin-2(1H)-one (CAS 477846-49-4), molecular formula C19H16ClNO3 and molecular weight 341.79 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 3-(4-Chlorobenzyl)-4-hydroxy-1-(4-methoxyphenyl)pyridin-2(1H)-one (C19H16ClNO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 341.79 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC19H16ClNO3
Molecular Weight341.79 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentCl-containing
Nitrogen Atoms1

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