N-(4-bromophenyl)-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxamide CAS 477858-02-9
| CAS No. | 477858-02-9 |
| Molecular Formula | C18H13BrClNOS2 |
| Molecular Weight | 438.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-bromophenyl)-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxamide.
N-(4-bromophenyl)-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxamide (CAS 477858-02-9), molecular formula C18H13BrClNOS2 and molecular weight 438.79 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine/bromine substitution, N-(4-bromophenyl)-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 438.79 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-bromophenyl)-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13BrClNOS2 |
| Molecular Weight | 438.79 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
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- (2E)-3-{4-[(4-bromophenyl)methoxy]phenyl}-N-(3-methoxyphenyl)prop-2-enamide (CAS 477889-44-4)
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Recommended Standards
- 2-[(tert-Butoxycarbonyl)amino]-3-(3-bromophenyl)-4-(4-chlorophenyl)butane (CAS 605680-54-4)
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- 4-((5-Chloro-6-oxo-1-(3-(trifluoromethyl)phenyl)-1,6-dihydropyridazin-4-yl)oxy)-3-ethoxybenzaldehyde (CAS 881464-17-1)
- Dacomitinib Impurity 12 (CAS CATO-C4X-208612)
- 4-(Naphthalen-2-ylmethoxy)benzaldehyde (CAS 172931-93-0)
- 1-(6-(Indolin-1-yl)-2-methylpyridin-3-yl)-N-methylmethanamine (CAS 1355194-91-0)
- 5-Methyl-4-m-tolylthiazol-2-ylamine (CAS 16942-67-9)
- 3-(Benzyl(methyl)amino)benzonitrile (CAS 1484725-76-9)
- 2-(Chloromethyl)-3-(pyridin-2-yl)quinazolin-4(3H)-one (CAS 76535-05-2)
- 2-Hydroxy-5-isopropoxy-N,N-dimethylbenzamide (CAS 1243353-50-5)
- N-ethyl-N-methylpyrrolidin-3-amine (CAS 1228458-45-4)
- (R)-Benzyl (4-hydroxybutan-2-yl)carbamate (CAS 866395-21-3)
- 1-[1-(1,3-thiazol-2-yl)ethyl]piperazine (CAS 1185539-23-4)
- Amyloid Precursor Frameshift Mutant C-Terminal Peptide trifluoroacetate salt (CAS 189125-14-2)
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