3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-phenylurea CAS 477864-64-5
| CAS No. | 477864-64-5 |
| Molecular Formula | C18H13ClF3N5O |
| Molecular Weight | 407.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-phenylurea is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-phenylurea (CAS 477864-64-5), a certified reference material (molecular formula C18H13ClF3N5O, MW 407.78 g/mol) for analytical method development and quality control.
Based on its molecular formula C18H13ClF3N5O, 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-phenylurea contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 407.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-phenylurea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13ClF3N5O |
| Molecular Weight | 407.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related chloro Standards
- 3-Chloro-N'-methyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]benzohydrazide (CAS 672951-01-8)
- 4-Chloro-N'-methyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)benzohydrazide (CAS 672950-95-7)
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea (CAS 228400-44-0)
- 2-[4-Chloro-3-(trifluoromethyl)benzenesulfonamido]-3-phenylpropanoic acid (CAS 1008052-19-4)
- N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-[(4-methylphenyl)sulfonyl]glycine (CAS 592471-10-8)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 338775-17-0)
- (3E)-2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(morpholin-4-yl)-4-phenylbut-3-enenitrile (CAS 321432-67-1)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-isopropylphenyl)-1H-pyrrole-2-carboxamide (CAS 338956-40-4)
Recommended Standards
- 2-Amino-6-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}pyridine-3,5-dicarbonitrile (CAS 338410-24-5)
- 2-((3-Chlorophenyl)amino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 667905-37-5)
- (3E)-3-[Amino({4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl})methylidene]prop-1-ene-1,1,3-tricarbonitrile (CAS 338410-25-6)
- Bis(pentamethylcyclopentadienyl)barium (CAS 112379-49-4)
- 2-Amino-4-fluoro-5-methoxybenzenethiol (CAS 1343435-68-6)
- 1,1-Dimethyl-1,2,3,4-tetrahydroisoquinolin-6-ol (CAS 25200-13-9)
- N-(2-Amino-4-methoxyphenyl)-2-methylpropanamide (CAS 436090-31-2)
- 5-(3-Chlorophenyl)-3-methoxypicolinonitrile (CAS 1415226-39-9)
- 3,3-Bis(bromomethyl)-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine (CAS 701209-98-5)
- Cabozantinib Impurity 11 (CAS 748707-58-6)
- 5-Bromo-3-pentyloxyphenylboronic acid (CAS 2121512-33-0)
- 2-Chloro-5,7-difluorobenzo[d]thiazole (CAS 791594-34-8)
- PPPA (CAS 113190-92-4)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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