3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-[3-(trifluoromethyl)phenyl]urea CAS 477864-65-6
| CAS No. | 477864-65-6 |
| Molecular Formula | C19H12ClF6N5O |
| Molecular Weight | 475.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-[3-(trifluoromethyl)phenyl]urea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-[3-(trifluoromethyl)phenyl]urea (CAS 477864-65-6), a certified reference material (molecular formula C19H12ClF6N5O, MW 475.77 g/mol) for analytical method development and quality control.
The molecular framework of 3-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1-[3-(trifluoromethyl)phenyl]urea (C19H12ClF6N5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C19H12ClF6N5O |
| Molecular Weight | 475.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related chloro Standards
- (3-(4-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1H-pyrazol-1-yl)(3,4-dichlorophenyl)methanone (CAS 477710-99-9)
- 3-{3-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1-(3,4-dichlorobenzoyl)-1H-pyrazole (CAS 477711-70-9)
- 3-(2-Chloro-6-fluorophenyl)-5-methyl-N-{3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}-1,2-oxazole-4-carboxamide (CAS 1092346-37-6)
- (2Z)-2-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 1025277-30-8 MS-9216 (CAS 1025277-30-8)
- 6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one (CAS 1354745-52-0)
- 2-(N-(2-chloro-5-(trifluoromethyl)phenyl)methylsulfonamido)-N-(2,4-dichlorophenyl)acetamide (CAS 339018-84-7)
- (E)-{1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethylidene}({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy})amine (CAS 338978-43-1)
- 3-Chloro-2-[(E)-2-{[4-(2,4-dichlorobenzoyl)-1-methyl-1H-pyrrol-2-yl]methylidene}hydrazin-1-yl]-5-(trifluoromethyl)pyridine (CAS 338795-39-4)
Recommended Standards
- 4-(4-(4-Bromophenyl)-5-((2-chloro-6-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 477330-23-7)
- N-Lignoceroyl Taurine (CAS 807370-75-8)
- 3-(4-(4-Bromophenyl)-5-((2-chloro-6-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 678541-90-7)
- 3-(Trifluoromethyl)phenyl 2-{N-[2-chloro-5-(trifluoromethyl)phenyl]methanesulfonamido}acetate (CAS 866131-07-9)
- N-Methyl-1H-imidazole-1-carboxamide (CAS 72002-25-6)
- 5-Bromo-2-(2-methoxyphenoxy)aniline (CAS 946786-62-5)
- 4-(4-Methyl-1,2,5-oxadiazol-3-yl)thiazol-2-amine (CAS 339311-69-2)
- 2-(Acridin-9-ylamino)ethanol (CAS 4665-56-9)
- 2-Chloro benzyl mercaptan (CAS 39718-00-8)
- 2-(2,1,3-Benzothiadiazole-4-sulfonyl)acetic acid (CAS 706766-79-2)
- 4-Benzyl 1-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (CAS 129799-14-0)
- n-Cyclohexyl-2-fluoroaniline (CAS 1019482-89-3)
- Triethyl phosphonoacetate-<SUP>13</SUP>C<SUB>2</SUB> (CAS 100940-60-1)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
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