4-(3-Hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile CAS 477864-74-7

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

4-(3-Hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile (CAS 477864-74-7), molecular formula C15H9N3O2 and molecular weight 263.25 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4-(3-Hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile (C15H9N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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