2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-(4-chlorophenyl)acetonitrile CAS 477865-22-8
| CAS No. | 477865-22-8 |
| Molecular Formula | C14H7Cl2F3N2S |
| Molecular Weight | 363.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 363.18 g/mol gives 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-(4-chlorophenyl)acetonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-(4-chlorophenyl)acetonitrile (CAS 477865-22-8), molecular formula C14H7Cl2F3N2S and molecular weight 363.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-(4-chlorophenyl)acetonitrile (C14H7Cl2F3N2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H7Cl2F3N2S |
| Molecular Weight | 363.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- [(3Z)-5-Chloro-1-[(4-chlorophenyl)methyl]-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino acetate (CAS 320420-90-4)
- 2-Chloro-4-(3-(4-fluorophenyl)ureido)benzene-1-sulfonyl chloride (CAS 680617-72-5)
- (E)-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene}[(4-chlorophenyl)methoxy]amine (CAS 866132-27-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-chlorobenzyl)acetamide (CAS 478063-70-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-chlorophenyl)propanamide (CAS 303148-07-4)
- N-(3-chloro-4-methylphenyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetamide (CAS 477890-08-7)
- 7-Chloro-2-(2-(5-nitrofuran-2-yl)vinyl)quinoline-4-carbonyl chloride (CAS 114119-30-1)
- 1-chloro-4-[(4-chloro-3-nitrophenyl)(difluoro)methyl]-2-nitrobenzene (CAS 1545-61-5)
Recommended Standards
- Ethyl 5-bromo-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate (CAS 1956385-71-9)
- 4-Benzyl-8-bromo-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (CAS 2361423-97-2)
- Prop-2-yn-1-yl 3-bromo-4-((2-fluorobenzyl)oxy)benzoate (CAS 1706445-25-1)
- 8-Bromo-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)imidazo[1,5-c]pyrimidin-5-amine (CAS 2170605-15-7)
- Diethyl 2-(ureidomethylene)malonate (CAS 61679-84-3)
- 2,2-bis(chloranyl)-1,1-bis(fluoranyl)-7,7a-dihydro-2aH-cyclobuta[a]indene 2,2-dichloro-1,1-difluoro-7,7a-dihydro-2aH-cyclobuta[a]indene 7570-45-8 A838490 (CAS 7570-45-8)
- 2-(Naphthalen-1-yl)ethanesulfonyl chloride (CAS 104296-63-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
- 4-Oxo-4-((3-(3-phenylpropanamido)phenyl)amino)butanoic acid (CAS 940507-15-3)
- Metoprolol Impurity 12 (CAS 32846-01-8)
- N-(5-chloro-2-methoxyphenyl)-N-(1-phenylcyclopentyl)formamide (CAS 1018060-65-5)
- 3-Bromo-5-(difluoromethyl)phenol (CAS 770718-98-4)
- N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-((3-cyano-6-(3,4-dimethoxyphenyl)-4-(trifluoromethyl)pyridin-2-yl)thio)acetamide (CAS 496798-64-2)
- Casein kinase II peptide Substrate (CAS 154444-98-1)
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