Sacubitril impurity 54 CAS 149709-63-7
| CAS No. | 149709-63-7 |
| Molecular Formula | C24H29NO5 |
| Molecular Weight | 411.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Sacubitril impurity 54 (CAS 149709-63-7) is a certified pharmaceutical impurity reference standard with the molecular formula C24H29NO5 and a molecular weight of 411.49 g/mol.
Sacubitril impurity 54 (C24H29NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H29NO5 |
| Molecular Weight | 411.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril impurity 45 (CAS 761373-05-1)
- Sacubitril Impurity 32 (CAS CATO-C4X-280932)
- Sacubitril Impurity C32 (CAS 1817838-91-7)
- Sacubitril Impurity 7 (CAS CATO-C4X-28097)
- Sacubitril-d4 (CAS 1884269-07-1)
- Sacubitril impurity 19 (CAS CATO-C4X-280919)
- Sacubitril Impurity 20 (CAS 2459446-51-4)
- Sacubitril Impurity 37 (CAS CATO-C4X-280937)
Recommended Standards
- Salbutamol Impurity N19 (CAS 77430-27-4)
- Drotaveraldine (CAS 54088-62-9)
- Fmoc-N-Me-Thr(tBu)-OH (CAS 117106-20-4)
- Drotaverine Impurity 3 (CAS CATO-C4X-24353)
- Mizolastine Impurity 10 (CAS CATO-C4X-200610)
- Mirogabalin Impurity 134 (CAS CATO-C4X-2924134)
- Iopromide Impurity 20 (CAS CATO-C4X-183220)
- 1-(3-Ethoxy-5-fluorophenyl)ethan-1-ol (CAS 1443343-85-8)
- N~1~-Benzyl-N~1~,4-dimethyl-1,2-benzenediamine (CAS 1097786-19-0)
- 2-Amino-N-isopropyl-N-((S)-1-methyl-piperidin-3-yl)-acetamide (CAS 1354003-55-6)
- N-Benzyladriamycin-14-Valerate (AD 198) (CAS 98983-21-2)
- 4-[4-(2-methyl-5-nitrobenzenesulfonyl)piperazin-1-yl]-4-oxobutanoic acid (CAS 744264-22-0)
- 4-Amino-2-mercapto-5-(4-phenyl-2-thiazolyl)-3-azaspiro[5.5]undeca-1,3-diene-1-carbonitrile (CAS 384860-61-1)
- Myristoyl Pentapeptide -4 acetate (CAS 959610-30-1(free base))
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