N'-[(1E)-{4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-4-(trifluoromethyl)benzohydrazide CAS 477868-66-9
| CAS No. | 477868-66-9 |
| Molecular Formula | C19H13ClF3N3O2S |
| Molecular Weight | 439.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
N'-[(1E)-{4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-4-(trifluoromethyl)benzohydrazide (CAS 477868-66-9), molecular formula C19H13ClF3N3O2S and molecular weight 439.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N'-[(1E)-{4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-4-(trifluoromethyl)benzohydrazide (C19H13ClF3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H13ClF3N3O2S |
| Molecular Weight | 439.84 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Recommended Standards
- Ethyl 5-[(4-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate (CAS 338956-93-7)
- N-[4-(2-Chlorobenzenesulfonyl)phenyl]-3-(trifluoromethyl)benzamide (CAS 339105-70-3)
- Ethyl 5-[(3-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate (CAS 338957-58-7)
- 4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-N-((dimethylamino)methylene)benzamide (CAS 1164512-96-2)
- 3-(4-(Methylsulfonyl)phenoxy)pyrrolidine (CAS 1250231-62-9)
- N-[(11bR)-2,6-Di-2-naphthalenyl-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoromethanesulfonamide (CAS 1010800-01-7)
- Methyl 2-(1-ethyl-1h-imidazol-5-yl)-2-hydroxyacetate (CAS 1495898-02-6)
- 6-Acetyl-4-hydroxynicotinaldehyde (CAS 1393539-74-6)
- 2-Amino-N-isopropyl-3-phenyl-DL-propanamide (CAS 100316-78-7)
- (2-Fluorophenyl)(4-methoxy-3-nitrophenyl)methanone (CAS 66938-39-4)
- 4-(4-Methoxyphenoxy)butan-2-one (CAS 32352-97-9)
- tert-Butyl (2-oxo-2-(thiazol-2-ylamino)ethyl)carbamate (CAS 1037560-78-3)
- 1-(1,2-Diethyl-1H-imidazol-5-yl)-3-(dimethylamino)prop-2-en-1-one (CAS 600638-92-4)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com