4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-N-((dimethylamino)methylene)benzamide CAS 1164512-96-2
| CAS No. | 1164512-96-2 |
| Molecular Formula | C20H21ClF3N5O |
| Molecular Weight | 439.86 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-N-((dimethylamino)methylene)benzamide (CAS 1164512-96-2) is a high-purity analytical reference standard with the molecular formula C20H21ClF3N5O and a molecular weight of 439.86 g/mol.
4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-N-((dimethylamino)methylene)benzamide (C20H21ClF3N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21ClF3N5O |
| Molecular Weight | 439.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Chloro Standards
- 4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-(methylthio)quinazoline (CAS 866138-05-8)
- 5-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}-4-phenyl-4H-1,2,4-triazole-3-thiol (CAS 338397-26-5)
- 6-Chloro-3,4-dihydro-N-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide (CAS 745-75-5)
- N-(5-chloro-2-methylphenyl)-2-((3-cyano-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-2-yl)thio)acetamide (CAS 626227-77-8)
- 2-Chloro-4-fluoro-N-((3-(5-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-51-8)
- 2-Chloro-4-fluoro-N-((3-(6-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-50-7)
- 2-Chloro-4-fluoro-N-((4-(6-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-85-8)
- 3-Chloro-N-((3-(1-(4-fluorophenyl)-1H-pyrazol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 318951-75-6)
Recommended Standards
- N-[4-(2-Chlorobenzenesulfonyl)phenyl]-3-(trifluoromethyl)benzamide (CAS 339105-70-3)
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-chloro-4-fluorophenyl)propanoic acid (CAS 1217680-33-5)
- N'-[(1E)-{4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-4-(trifluoromethyl)benzohydrazide (CAS 477868-66-9)
- Fmoc-D-2-Fluoro-4-chlorophenylalanine (CAS 1217768-67-6)
- 5,7-Dichloro-2,3-dihydroquinolin-4(1H)-one hydrochloride (CAS 1272758-06-1)
- 7-Bromoisoquinoline-3-carbaldehyde (CAS 1824311-77-4)
- 8-Bromoimidazo[1,2-a]pyrazine (CAS 69214-34-2)
- N-(2-(Benzo[d]oxazol-2-yl)ethyl)-[1,1'-biphenyl]-4-sulfonamide (CAS 926283-46-7)
- 3-((3-Fluorophenyl)(methyl)amino)propanoic acid hydrochloride (CAS 1185293-67-7)
- (3,4-Dihydro-2h-1-benzopyran-6-yl)methanamine (CAS 55746-21-9)
- 2-((4-(N-isopropylsulfamoyl)phenyl)carbamoyl)cyclohexane-1-carboxylic acid (CAS 817187-19-2)
- Pentane-2,4-diyldibenzene (CAS 1145-23-9)
- ethyl 5-methylimidazo[2,1-b]thiazole-6-carboxylate (CAS 57332-81-7)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
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