4-{[1,1'-biphenyl]-4-yl}-2-(3-fluoro-4-iodophenyl)pyrimidine CAS 477870-86-3
| CAS No. | 477870-86-3 |
| Molecular Formula | C22H14FIN2 |
| Molecular Weight | 452.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-{[1,1'-biphenyl]-4-yl}-2-(3-fluoro-4-iodophenyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-{[1,1'-biphenyl]-4-yl}-2-(3-fluoro-4-iodophenyl)pyrimidine (CAS 477870-86-3), molecular formula C22H14FIN2 and molecular weight 452.26 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/iodine substitution, 4-{[1,1'-biphenyl]-4-yl}-2-(3-fluoro-4-iodophenyl)pyrimidine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 452.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C22H14FIN2 |
| Molecular Weight | 452.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related biphenyl Standards
- 2-[(3-{[1,1'-biphenyl]-4-yl}-1-phenyl-1H-pyrazol-4-yl)methylidene]-2,3-dihydro-1H-indene-1,3-dione (CAS 956741-95-0)
- (Z)-3-(3-([1,1'-biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)-2-(3-methoxyphenyl)acrylonitrile (CAS 956782-17-5)
- (2-Biphenyl)di-1-adamantylphosphine (CAS 224311-55-1)
- N-([1,1'-Biphenyl]-2-yl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 577998-00-6)
- 3,5-Di([1,1'-biphenyl]-4-yl)-4-phenyl-4H-1,2,4-triazole (CAS 387391-50-6)
- 11-([1,1'-Biphenyl]-4-yl)-5-bromo-11H-benzo[a]carbazole (CAS 1210469-50-3)
- 2-[10-([1,1'-Biphenyl]-4-yl)anthracen-9-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1416243-42-9)
- 2-(10-([1,1'-Biphenyl]-3-yl)anthracen-9-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1510788-38-1)
Recommended Standards
- 4-(4-(Tributylstannyl)phenyl)morpholine (CAS 1257527-55-1)
- 2,3,3a,6,7,7a-Hexahydro-2S,7a-dimethyl-4-hydroxy-indene-1R-(1-iodo)ethane 4-O-Trifluoromethylsulfonate (CAS 145372-33-4)
- Crisaborole lmpurity 81 (CAS CATO-C4X-202181)
- N-(4-((4-bromophenyl)sulfonyl)phenyl)-2,6-difluorobenzamide (CAS 339104-64-2)
- 5-Bromo-4-fluoro-1H-indole (CAS 344790-96-1)
- 1-chloro-4-{[(chloromethyl)sulfanyl]methyl}benzene (CAS 15894-25-4)
- (R)-N-(4-(1-aminoethyl)phenyl)acetamide (CAS 177948-74-2)
- (E)-N-(2,4-dimethoxyphenyl)-3-(2,3,4-trimethoxyphenyl)acrylamide (CAS 329778-90-7)
- 2-(Chloromethyl)benzo[d]oxazole-5-carboxaldehyde (CAS 1803855-65-3)
- Trenbolone-Acetate (CAS 10161-34-9)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluoro-4-methylphenyl)acetamide (CAS 477329-74-1)
- (3-(Pyrimidin-2-yl)phenyl)methanamine (CAS 910036-92-9)
- alpha-Tocopherol Phosphate Disodium Salt (CAS 90940-45-7)
- Semaglutide Impurity 190 (CAS CATO-C4X-2226190)
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