N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-N-[(hydroxyamino)methylene]thiourea CAS 477873-17-9
| CAS No. | 477873-17-9 |
| Molecular Formula | C8H6ClF3N4OS |
| Molecular Weight | 298.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 298.67 g/mol gives N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-N-[(hydroxyamino)methylene]thiourea distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-N-[(hydroxyamino)methylene]thiourea (CAS 477873-17-9) is a high-purity analytical reference standard with the molecular formula C8H6ClF3N4OS and a molecular weight of 298.67 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-N-[(hydroxyamino)methylene]thiourea is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 298.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-N-[(hydroxyamino)methylene]thiourea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3N4OS |
| Molecular Weight | 298.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 3,5-Diphenyl-2-thioxoimidazolidin-4-one (CAS 61815-22-3)
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- 6-Oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic Acid (CAS 27372-38-9)
- 4-Amino-2-hydroxybenzenesulfonamide (CAS 647830-76-0)
- 2-(Ethylthio)-5-(1-tosylpiperidin-2-yl)pyridine (CAS 1352503-99-1)
- 2,4-Dimethylbenzylamine (CAS 94-98-4)
- 2-[5-(Hydroxymethyl)-3-methyl-1,3-oxazolidin-2-ylidene]-3-(3-oxo-1,3-dihydro-2H-indol-2-ylidene)propanenitrile (CAS 425399-08-2)
- 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-pyridylmethyl)thiourea (CAS 1024572-85-7)
- 2-Chloro-5-{[4-(thiophene-2-sulfonyl)piperazin-1-yl]sulfonyl}benzoic acid (CAS 742118-92-9)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
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