N'-[(1E)-{3-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-3,4,5-trimethoxybenzohydrazide CAS 477886-84-3
| CAS No. | 477886-84-3 |
| Molecular Formula | C21H20ClN3O5S |
| Molecular Weight | 461.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
N'-[(1E)-{3-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-3,4,5-trimethoxybenzohydrazide (CAS 477886-84-3) is a high-purity analytical reference standard with the molecular formula C21H20ClN3O5S and a molecular weight of 461.92 g/mol.
N'-[(1E)-{3-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methylidene]-3,4,5-trimethoxybenzohydrazide (C21H20ClN3O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20ClN3O5S |
| Molecular Weight | 461.92 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Recommended Standards
- 4-[(5E)-5-[(4-Chloro-3-nitrophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-azatricyclo[5.2.1.0^{2,6}]dec-8-ene-3,5-dione (CAS 477766-88-4)
- Ticagrelor Impurity 116 (CAS 1863036-47-8)
- 5''-Chloro-N-((5,6-dimethoxypyridin-2-yl)methyl)-[2,2':5',3''-terpyridine]-3'-carboxamide (CAS 1207253-08-4)
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- Proligestone (CAS 23873-85-0)
- 4-Chloro-2-methylpyrimidine dihydrochloride (CAS 1159824-34-6)
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- N-(2-(Pyridin-4-yl)pyrimidin-4-yl)hexanamide (CAS 61310-42-7)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
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