(2E)-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-3-[(4-fluorophenyl)amino]prop-2-en-1-one CAS 477888-40-7
| CAS No. | 477888-40-7 |
| Molecular Formula | C22H16ClF2NO2 |
| Molecular Weight | 399.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (2E)-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-3-[(4-fluorophenyl)amino]prop-2-en-1-one (CAS 477888-40-7), a certified reference material (molecular formula C22H16ClF2NO2, MW 399.82 g/mol) for analytical method development and quality control.
Based on its molecular formula C22H16ClF2NO2, (2E)-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-3-[(4-fluorophenyl)amino]prop-2-en-1-one contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 399.82 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2E)-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-3-[(4-fluorophenyl)amino]prop-2-en-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H16ClF2NO2 |
| Molecular Weight | 399.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- (E)-1-{3-[(2-Chloro-6-fluorobenzyl)oxy]phenyl}-3-(4-fluoroanilino)-2-propen-1-one (CAS 478039-90-6)
- 5-Chloro-2-((4-nitrophenyl)carbamoyl)phenyl dimethylsulfamate (CAS 400080-38-8)
- (E)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-4-(2-(thiophen-2-yl)vinyl)pyrimidine (CAS 339278-44-3)
- 2-[(2-Chloro-6-fluorophenyl)methyl]-4-[(1E)-{[(3-methoxyphenyl)methyl]imino}methyl]benzene-1,3-diol (CAS 341967-51-9)
- N-(4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)urea (CAS 478262-19-0)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-morpholinophenyl)acetamide (CAS 685108-01-4)
- 4-Chloro-6-(4-methoxyphenyl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1649455-09-3)
- (1-(3-Chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)(4-(4-methylpiperazin-1-yl)phenyl)methanone (CAS 866135-70-8)
Recommended Standards
- methyl 4-benzyl-6-(4-chlorophenyl)-1,3-dioxohexahydro-1H-furo[3,4-c]pyrrole-4-carboxylate (CAS 1005085-90-4)
- 1-((4-Chlorophenyl)sulfonyl)-4-(2-fluoro-4-nitrophenyl)piperazine (CAS 866131-33-1)
- 4-Ethoxy-3-(3-(3-nitrophenyl)ureido)benzene-1-sulfonyl chloride (CAS 678185-98-3)
- N-(2-(5-(4-Chlorophenyl)furan-2-carbonyl)-4,5-dimethoxyphenyl)acetamide (CAS 886493-79-4)
- tert-Butyl N-(1H-1,2,3-triazol-4-yl)carbamate (CAS 1443981-13-2)
- 3-(3-(Trifluoromethyl)phenyl)oxetan-3-amine (CAS 1349972-70-8)
- [2-(Tert-butoxycarbonylamino)-3-cyano-7-fluoro-benzothiophen-4-yl]boronic acid (CAS 2892621-47-3)
- 4-(Pyridin-2-yldiazenyl)naphthalen-1-ol (CAS 7385-98-0)
- 2-Amino-5h,7h,8h-pyrano[4,3-b]pyridine-3-carbonitrile (CAS 1250721-65-3)
- 3-(Carbobenzoxyamino)-1-propanol 3-(Cbz-amino)-1-propanol 34637-22-4 Benzyl N-(3-Hydroxypropyl)carbamate C1932 N-(3-Hydroxypropyl)carbamic Acid Benzyl Ester (CAS 34637-22-4)
- Methyl 4-chloro-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (CAS 2377611-92-0)
- 4-Chloro-N-ethylpyridine-3-sulfonamide (CAS 59582-90-0)
- 4-Chloro-6-(difluoromethyl)pyrimidine (CAS 1261737-05-6)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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