(2E)-3-{[4-chloro-2-(trifluoromethyl)phenyl]amino}-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one CAS 477888-52-1
| CAS No. | 477888-52-1 |
| Molecular Formula | C23H15Cl2F4NO2 |
| Molecular Weight | 484.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (2E)-3-{[4-chloro-2-(trifluoromethyl)phenyl]amino}-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one (C23H15Cl2F4NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
(2E)-3-{[4-chloro-2-(trifluoromethyl)phenyl]amino}-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 477888-52-1) is a high-purity analytical reference standard with the molecular formula C23H15Cl2F4NO2 and a molecular weight of 484.27 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures (2E)-3-{[4-chloro-2-(trifluoromethyl)phenyl]amino}-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H15Cl2F4NO2 |
| Molecular Weight | 484.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- 3'-Chloro-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-5'-(trifluoromethyl)-4H-[1,2'-bipyridin]-4-one (CAS 303151-90-8)
- 2-Chloro-N-[4-(2-chlorobenzenesulfonyl)phenyl]-4-methanesulfonylbenzamide (CAS 251096-73-8)
- N-(2-Chloro-4,6-dimethylphenyl)-2-((4-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476483-97-3)
- 2-[2-[2-Chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,3,3-trimethyl-3H-indolium tetrafluoroborate(1-) (CAS 439859-04-8)
- N-(3-chloro-4-methylphenyl)-2-((3-ethyl-4-oxo-7-(p-tolyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide (CAS 1040632-72-1)
- N-(5-chloro-2-methylphenyl)-2-((3-ethyl-4-oxo-7-(p-tolyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide (CAS 1040632-77-6)
- N-(2-chloro-4-methylphenyl)-2-((3-ethyl-4-oxo-7-(p-tolyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide (CAS 1040632-82-3)
- N-(3-Chloro-4-methylphenyl)-2-((3-cyano-4-phenyl-6-(p-tolyl)pyridin-2-yl)thio)acetamide (CAS 444153-50-8)
Recommended Standards
- 2-(Tributylstannyl)phenanthridin-6(5H)-one (CAS 98708-04-4)
- Brivaracetam Impurity 89 (CAS CATO-C4X-200789)
- 2-(Tributylstannyl)acridin-9(10H)-one (CAS 98708-03-3)
- Isothiazole Impurity 2 (CAS 252004-60-7)
- 2-Hydroxy-N,N-dimethyl-4-(trifluoromethyl)benzamide (CAS 1243434-94-7)
- 9-(2-Pyridyl)carbazole (CAS 23866-67-3)
- Benzyl 3-(methylsulfamoyl)propanoate (CAS 1424042-10-3)
- 2-(4-Methylpyridin-2-yl)acetic acid (CAS 149605-62-9)
- Ethyl 4-hydroxythieno[2,3-b]pyridine-5-carboxylate (CAS 55503-31-6)
- (S)-1-(9-Fluorenyl) Ethanol (CAS 151775-20-1)
- Loratadine Impurity 44 (CAS CATO-C4X-142644)
- 3-(1-(3-(2-Chlorophenyl)acryloyl)azetidin-3-yl)thiazolidine-2,4-dione (CAS 1799260-52-8)
- ({3,5-dimethyl-4-[(4-methylphenyl)methoxy]phenyl}methyl)(ethyl)amine hydrochloride (CAS 1311315-64-6)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com