Isothiazole Impurity 2 CAS 252004-60-7
| CAS No. | 252004-60-7 |
| Molecular Formula | C18H12BrF2N3O4S |
| Molecular Weight | 484.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Isothiazole Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Isothiazole Impurity 2 (CAS 252004-60-7) is a certified pharmaceutical impurity reference standard with the molecular formula C18H12BrF2N3O4S and a molecular weight of 484.27 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Isothiazole Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 484.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H12BrF2N3O4S |
| Molecular Weight | 484.27 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Isothiazole Standards
- Isothiazole Impurity 3 (CAS 252004-29-8)
- Isothiazole Impurity 1 (CAS 252004-30-1)
- Ethyl isothiazole-3-carboxylate 1,1-dioxide (CAS 1823946-00-4)
- Isothiazole-4-sulfonyl chloride (CAS 88982-55-2)
- Isothiazole-5-sulfonyl chloride (CAS 362658-19-3)
- Isothiazole-4,5-dicarboxylic acid (CAS 66882-70-0)
- Isothiazole-3,4,5-tricarbonitrile (CAS 857958-14-6)
- Ethyl isothiazole-3-carboxylate (CAS 23244-32-8)
Recommended Standards
- Brivaracetam Impurity 89 (CAS CATO-C4X-200789)
- (1S,2S)-1,2-bis(3,5-bis(trifluoromethyl)phenyl)ethane-1,2-diamine (CAS 1262516-72-2)
- (2E)-3-{[4-chloro-2-(trifluoromethyl)phenyl]amino}-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 477888-52-1)
- 2-(2,6-dioxo-3-piperidyl)-4-(6-iodohexoxy)isoindoline-1,3-dione (CAS 2738912-34-8)
- Eldecalcitol Impurity 80 (CAS CATO-C4X-214080)
- Fondaparinux Sodium Impurity 6 (CAS CATO-C4X-20526)
- Iguratimod Impurity 106 (CAS CATO-C4X-1826106)
- Bromfenac Impurity 2 (CAS CATO-C4X-20022)
- S-Hydroprene (CAS 65733-18-8)
- 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole (CAS 1309788-50-8)
- 2,2,2-Trifluoro-1-(4-methyl-1,3-thiazol-2-yl)ethyl 4-methylbenzene-1-sulfonate (CAS 1375471-76-3)
- N-(1-Acetyl-5-methyl-1H-pyrazol-3-yl)acetamide (CAS 667423-35-0)
- 4-Bromo-3,3,4,4-tetrafluorobutyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1923267-08-6)
- Endo-Pro36-Tirzepatide (CAS CATO-CPTD788688)
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