7-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-2-methylpyrazolo[1,5-a]pyrimidine CAS 477888-66-7
| CAS No. | 477888-66-7 |
| Molecular Formula | C21H18FN3O |
| Molecular Weight | 347.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 7-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-2-methylpyrazolo[1,5-a]pyrimidine is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
7-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-2-methylpyrazolo[1,5-a]pyrimidine (CAS 477888-66-7) is a high-purity analytical reference standard with the molecular formula C21H18FN3O and a molecular weight of 347.39 g/mol.
The molecular framework of 7-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-2-methylpyrazolo[1,5-a]pyrimidine (C21H18FN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18FN3O |
| Molecular Weight | 347.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluoro Standards
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- N-(3-Fluoro-4-methylphenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 734535-32-1)
- 2-Fluoro-N-(2-(2-(pyrimidin-2-yl)-1H-imidazol-1-yl)ethyl)benzenesulfonamide (CAS 1797718-45-6)
- 7-Fluoro-2-[(4-fluoroanilino)methylene]-3-phenyl-1-indanone (CAS 339115-72-9)
- N-(2-Fluoro-5-methylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-amine (CAS 1775499-85-8)
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Recommended Standards
- 6-Benzyl-2-benzylidene-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione (CAS 463364-60-5)
- Dimethyl 5-(m-tolyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate 2-oxide (CAS 339113-52-9)
- 6,7-Dimethyl 5-(4-methoxyphenyl)-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate (CAS 339113-35-8)
- Dimethyl 5-(p-tolyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate 2-oxide (CAS 337920-83-9)
- 1-(2-Chlorophenyl)-3-(ethoxycarbonyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid (CAS 1264047-52-0)
- tert-Butyl (S)-(3-hydroxybutyl)carbamate (CAS 1311368-95-2)
- Clomacran (CAS 5310-55-4)
- Ethyl 5-(hex-1-yn-1-yl)nicotinate (CAS 662138-52-5)
- Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） (CAS 1049-84-9 (free base))
- trans-3,5-Dihydroxy-piperidine-1-carboxylic acid tert-butyl ester (CAS 1271240-62-0)
- Phenol, 4-(1,1,3,3-tetramethylbutyl)-, polymer with ethyne (CAS 68110-11-2)
- Sulfasymazine (CAS 1984-94-7)
- 3-Bromo-1-vinyl-1H-pyrazole (CAS 923036-00-4)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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