(2E)-N-Benzyl-3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-N-methylprop-2-enamide CAS 477888-88-3
| CAS No. | 477888-88-3 |
| Molecular Formula | C24H21Cl2NO2 |
| Molecular Weight | 426.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(2E)-N-Benzyl-3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-N-methylprop-2-enamide (CAS 477888-88-3), molecular formula C24H21Cl2NO2 and molecular weight 426.34 g/mol, is a CATO reference standard with documented purity and traceability.
(2E)-N-Benzyl-3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-N-methylprop-2-enamide (C24H21Cl2NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21Cl2NO2 |
| Molecular Weight | 426.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (2E)-1-{3-[(2,4-dichlorophenyl)methoxy]phenyl}-3-[(4-ethylphenyl)amino]prop-2-en-1-one (CAS 478046-59-2)
- (Z)-{[2-(4-chlorophenyl)cyclopropyl](4-methoxyphenyl)methylidene}[(4-chlorophenyl)methoxy]amine (CAS 338962-91-7)
- (2-Chloro-4-(4-chlorophenoxy)phenyl)(1-methyl-4-phenylpyrrolidin-3-yl)methanone (CAS 478050-09-8)
- 1-(Tert-butyl) 4-ethyl 4-(4-bromobenzyl)piperidine-1,4-dicarboxylate (CAS 912617-73-3)
- (2,5-Dihydroxyphenyl)propionic acid (CAS 10538-47-3)
- 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1198425-56-7)
- 1-(3,4-Difluorophenyl)butan-1-one (CAS 23384-73-8)
- 1-[1-(3-bromophenyl)-5-methyl-1h-1,2,3-triazol-4-yl]ethan-1-one (CAS 1157061-37-4)
- Milnacipran Impurity 42 (Mixture of Enantiomers) (CAS 165259-95-0)
- 1-Bromo-2-chloro-5-(cyclopropylmethoxy)-4-nitrobenzene (CAS 1400644-63-4)
- 1,3-Bis(4-chlorophenyl)-1H-pyrazol-4-ol (CAS 1202030-43-0)
- 1-(4-Bromophenyl)-1,3-butanedione (CAS 4023-81-8)
- 2-(Dimethylamino)-5-methyl-1-(naphthalen-1-yl)hex-4-en-1-one (CAS 91025-81-9)
- (D-His1)-Exenatide trifluoroacetate salt (CAS 1678417-09-8)
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