6-Nitro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine CAS 477889-67-1
| CAS No. | 477889-67-1 |
| Molecular Formula | C7H3F3N4O2 |
| Molecular Weight | 232.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-Nitro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine (CAS 477889-67-1), molecular formula C7H3F3N4O2 and molecular weight 232.12 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 6-Nitro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine (C7H3F3N4O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 232.12 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H3F3N4O2 |
| Molecular Weight | 232.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 5-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 473994-55-7)
- 7-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 473994-56-8)
- 8-bromo-1,2-dihydroquinolin-2-one (CAS 67805-67-8)
- 4-bromo-2,3-dihydroisoquinolin-3-one (CAS 36963-50-5)
- Methyl 1-benzyl-2-(3-methoxy-3-oxopropyl)azetidine-2-carboxylate (CAS 1353160-88-9)
- Doxycycline5-sulfosalicylate (CAS 60683-15-0)
- (S)-3-amino-2-(2,3-dichlorobenzyl)propanoic acid (CAS 1260605-45-5)
- 3,3,3-Trifluoro-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one (CAS 125969-74-6)
- 4-(2,4-Dichlorophenoxy)-3-fluoroaniline (CAS 1039334-55-8)
- 2-Bromo-1-(4,5-dimethoxy-2-nitrophenyl)ethanone (CAS 33245-76-0)
- 1,3-Bis(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-59-2)
- N-(3-(2-Phenylmorpholino)propyl)-2-(trifluoromethyl)benzamide (CAS 953915-09-8)
- Benzoic acid, 2-amino-5-bromo-4-cyclopropyl-, methyl ester (CAS 2883760-83-4)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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