5-(4-Chlorophenyl)-2-(2,5-dichlorophenoxy)pyrimidine CAS 477890-46-3
| CAS No. | 477890-46-3 |
| Molecular Formula | C16H9Cl3N2O |
| Molecular Weight | 351.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Chlorophenyl)-2-(2,5-dichlorophenoxy)pyrimidine.
5-(4-Chlorophenyl)-2-(2,5-dichlorophenoxy)pyrimidine (CAS 477890-46-3) is a high-purity analytical reference standard with the molecular formula C16H9Cl3N2O and a molecular weight of 351.61 g/mol.
The molecular framework of 5-(4-Chlorophenyl)-2-(2,5-dichlorophenoxy)pyrimidine (C16H9Cl3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H9Cl3N2O |
| Molecular Weight | 351.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 4-(4-Chlorophenyl)-2-(2,5-dichlorophenoxy)pyrimidine (CAS 339106-07-9)
- 4-(4-Chlorophenyl)-2-(3,5-dichlorophenoxy)pyrimidine (CAS 339106-05-7)
- 1-(3-Chlorophenyl)-3-methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine (CAS 477708-95-5)
- 4-(4-Chlorophenyl)-3-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 400074-90-0)
- 1-(4-Chlorophenyl)-5-(4-fluorophenyl)-3-(methylsulfonyl)-1H-1,2,4-triazole (CAS 99793-75-6)
- 2-(4-Chlorophenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione (CAS 457049-99-9)
- 3-(2-Chlorophenyl)-5-[(E)-2-[(4-methoxyphenyl)amino]ethenyl]-1,2-oxazole-4-carbonitrile (CAS 320424-91-7)
- 2-(3-((4-Chlorophenyl)sulfonyl)-2-hydroxypropoxy)benzonitrile (CAS 478079-76-4)
Recommended Standards
- 4-Chloro-6-(2,4-dichlorophenoxy)-3-phenylpyridazine (CAS 477872-34-7)
- 6-Chloro-N-cyclopentyl-2-ethyl-5-iodopyrimidin-4-amine (CAS 917896-51-6)
- Hydroxychloroquine Impurity 91 (CAS CATO-C4X-183591)
- (E)-2-Acetoxy-2-bromo-5-chlorostilbene (CAS 1000890-01-6)
- 3-(Carboxymethyl)-5-methoxy-1H-indole-2-carboxylic acid (CAS 858232-58-3)
- N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)thiomorpholine-4-carboxamide (CAS 874298-05-2)
- Phenacaine-API (CAS 101-93-9)
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- 2-(2-(Bromomethyl)naphthalen-1-yl)acetonitrile (CAS 1256463-18-9)
- Bis-N1,N2-[2-[(4S)-4-(1,1-dimethylethyl)-4,5-dihydro-2-oxazolyl]phenyl]-1,2-benzenediamine (CAS 1616881-94-7)
- 3-Chloroquinoline (CAS 612-59-9)
- 8-Bromo-5-methoxyisoquinoline (CAS 521313-45-1)
- 3-Fluoro-2-hydroxypyridine (CAS 1547-29-1)
- Tau Peptide (275-305) (Repeat 2 Domain) trifluoroacetate salt (CAS 330456-25-2)
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