Hydroxychloroquine Impurity 91 CAS CATO-C4X-183591
| CAS No. | CATO-C4X-183591 |
| Molecular Formula | C16H9Cl3N2O |
| Molecular Weight | 351.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Hydroxychloroquine Impurity 91 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 351.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Hydroxychloroquine Impurity 91 (CAS CATO-C4X-183591, C16H9Cl3N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H9Cl3N2O |
| Molecular Weight | 351.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine EP Impurity A (CAS 1449223-88-4)
- Hydroxychloroquine impurity 81 (CAS CATO-C4X-183581)
- Hydroxychloroquine Impurity 89 (CAS CATO-C4X-183589)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
- Hydroxychloroquine Impurity 22 (CAS CATO-C4X-183522)
- Hydroxychloroquine impurity 64 (CAS CATO-C4X-183564)
- Hydroxychloroquine impurity 65 (CAS CATO-C4X-183565)
- Hydroxychloroquine Impurity 97 (CAS CATO-C4X-183597)
Recommended Standards
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- (E)-2-chloro-4-(2-(2,4-dichlorobenzylidene)hydrazinyl)quinazoline (CAS 129177-13-5)
- Cloransulam-Methyl Impurity 6 (CAS CATO-C4X-31706)
- Empagliflozin Impurity 110 (CAS CATO-C4X-1065110)
- Avanafil Impurity 46 (CAS 1624833-89-1)
- 6-(benzyloxymethyl)tetrahydropyran-3-one (CAS 1239018-95-1)
- Sodium perfluoro-1-hexane[18O2]sulfonate (CAS 1585941-14-5)
- 3,5-Dichloro-4-(difluoromethoxy)cinnamic acid (CAS 1807351-38-7)
- 2-Propenamide, N-(hydroxymethyl)-, polymer with 1,3-butadiene and ethenylbenzene (CAS 26591-53-7)
- 2-Methyl-3-[2-(4-nitrophenyl)-2-oxoethyl]naphthoquinone (CAS 88007-99-2)
- 3-p-Anisoyl Acacetin (CAS 874519-13-8)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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