1-(2,6-Dichlorobenzyl)-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one CAS 478043-08-2
| CAS No. | 478043-08-2 |
| Molecular Formula | C23H18Cl2N2O2 |
| Molecular Weight | 425.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(2,6-Dichlorobenzyl)-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(2,6-Dichlorobenzyl)-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one (CAS 478043-08-2), molecular formula C23H18Cl2N2O2 and molecular weight 425.31 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-(2,6-Dichlorobenzyl)-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one (C23H18Cl2N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 425.31 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H18Cl2N2O2 |
| Molecular Weight | 425.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichlorobenzyl Standards
- 3-(3,4-Dichlorobenzyl)-1-ethyl-4-tosyl-1,3-dihydro-2H-imidazol-2-one (CAS 383148-73-0)
- 2-((2,6-Dichlorobenzyl)thio)-1-methyl-4,5-diphenyl-1H-imidazole (CAS 339277-22-4)
- 2-((3,4-Dichlorobenzyl)thio)-1-methyl-4,5-diphenyl-1H-imidazole (CAS 339277-04-2)
- 2-((2,4-Dichlorobenzyl)thio)-3-ethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 618879-78-0)
- 2-((2,6-Dichlorobenzyl)thio)-3-ethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 587012-18-8)
- 2-((3,4-Dichlorobenzyl)thio)-3-ethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 351007-56-2)
- N3-(2,4-dichlorobenzyl)-N3-propyl-6-chloro-4-(trifluoromethyl)nicotinamide (CAS 680213-98-3)
- 3-(2,6-Dichlorobenzyl)-2-methyl-1-(3-(trifluoromethyl)benzyl)pyridin-4(1H)-one (CAS 339017-50-4)
Recommended Standards
- (1E,4E)-1-(2-{6-[(2,4-dichlorophenyl)methyl]pyridazin-3-yl}hydrazin-1-yl)-5-phenylpenta-1,4-dien-3-one (CAS 860649-39-4)
- 1,2,3,4,6,7,9-Heptachlorodibenzo-p-dioxin (CAS 58200-70-7)
- N'-[(1E)-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylidene]benzohydrazide (CAS 691884-01-2)
- 4-(4-Chlorobenzoyl)-1-[(3-chlorophenyl)methyl]-3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317822-32-5)
- 4-Ethyl-5-(4-methylphenyl)-4H-1,2,4-triazole-3-thiol (CAS 29527-31-9)
- 6-oxo-1,6-dihydropyridazine-3-carbohydrazide (CAS 98021-39-7)
- N9,N9,N10,N10-Tetraphenylanthracene-9,10-diamine (CAS 177799-11-0)
- 1-(3,5-Difluorophenyl)-3-(1,3-dioxolan-2-yl)propan-1-one (CAS 842124-03-2)
- 1-(4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)pentane-2,4-dione (CAS 858765-63-6)
- Methyl 1,5-bis(4-bromophenyl)-2-methyl-1H-pyrrole-3-carboxylate (CAS 881041-74-3)
- 1,2,3,4-Tetrahydroquinolin-6-amine (CAS 103796-41-4)
- (2R,3R,4S,5R)-2-(acetoxymethyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 142831-80-9)
- 1-methanesulfonylazetidin-3-ol (CAS 1344068-80-9)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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