2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile CAS 478043-27-5
| CAS No. | 478043-27-5 |
| Molecular Formula | C18H8ClF6N3 |
| Molecular Weight | 415.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile (CAS 478043-27-5) is a high-purity analytical reference standard with the molecular formula C18H8ClF6N3 and a molecular weight of 415.72 g/mol.
Based on its molecular formula C18H8ClF6N3, 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 415.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H8ClF6N3 |
| Molecular Weight | 415.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Bis Standards
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(3-chlorophenyl)acetonitrile (CAS 478043-30-0)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(4-chlorophenyl)acetonitrile (CAS 339104-13-1)
- 3-Phenyl-6-(trifluoromethyl)-5-((3-(trifluoromethyl)benzyl)thio)-1,2,4-triazine (CAS 478048-13-4)
- 4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine (CAS 866154-31-6)
- 4-[3,5-Bis(trifluoromethyl)benzoyl]-3-ethyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 1008411-48-0)
- 2-Phenyl-4-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)thiazole-5-carboxamide (CAS 400080-76-4)
- 1-Phenyl-3-((3-((3-(trifluoromethyl)phenoxy)methyl)-1H-1,2,4-triazol-5-yl)methoxy)-1H-1,2,4-triazole (CAS 338395-55-4)
- 3,3-Bis({[3-(trifluoromethyl)phenyl]methyl})pentane-2,4-dione (CAS 477847-82-8)
Recommended Standards
- tert-Butyl 3-(3-bromo-7-chloropyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate (CAS 877173-82-5)
- (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)(o-tolyl)methanone (CAS 321351-00-2)
- (2Z)-2-(4-chlorophenyl)-3-[4-(2,4-dichlorobenzoyl)-1-methyl-1H-pyrrol-2-yl]prop-2-enenitrile 338786-73-5 6F-061 (CAS 338786-73-5)
- 6-Chloro-3-(2,4-dichloro-5-isopropoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (CAS 339099-15-9)
- 3-(4-Aminophenoxymethyl)benzonitrile hydrochloride (CAS 1251924-79-4)
- 1-Phenyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-one (CAS 355154-95-9)
- 4-(Chloromethyl)-N-(thiazol-2-yl)benzamide (CAS 916791-23-6)
- Ethyl 5-methyl-4-oxo-1,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate (CAS 5479-43-6)
- Cyclopropyl(2,3-difluorophenyl)methanamine (CAS 1270391-38-2)
- 3-(4,6-Dimethyl-2-oxo-1,2-dihydropyrimidin-5-yl)propanoic acid hydrochloride (CAS 1421602-76-7)
- Selexipag (CAS 475086-01-2)
- 1-Methylpyrido[2,3-b]pyrazine-2,3(1H,4H)-dione (CAS 67074-71-9)
- (S)-2-amino-N-(3-fluorophenyl)propanamide (CAS 875628-31-2)
- Semaglutide impurity 269 (CAS CATO-C4X-2226269)
Why CATO?
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