4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine CAS 866154-31-6
| CAS No. | 866154-31-6 |
| Molecular Formula | C18H11F6N3O2 |
| Molecular Weight | 415.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine (CAS 866154-31-6) is a high-purity analytical reference standard with the molecular formula C18H11F6N3O2 and a molecular weight of 415.29 g/mol.
The molecular framework of 4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine (C18H11F6N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H11F6N3O2 |
| Molecular Weight | 415.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Bis Standards
- 3-Phenyl-6-(trifluoromethyl)-5-((3-(trifluoromethyl)benzyl)thio)-1,2,4-triazine (CAS 478048-13-4)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(2-chlorophenyl)acetonitrile (CAS 478043-27-5)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(3-chlorophenyl)acetonitrile (CAS 478043-30-0)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(4-chlorophenyl)acetonitrile (CAS 339104-13-1)
- Ethyl (5-((2-(trifluoromethyl)phenyl)carbamoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamate (CAS 1396680-83-3)
- N-[3-(Trifluoromethyl)phenyl]-11,15-dioxa-16-azatetracyclo[8.7.0.0^{2,7}.0^{13,17}]heptadeca-1(10),2(7),3,5,8-pentaene-16-carboxamide (CAS 477853-81-9)
- 5-[3-(Trifluoromethyl)phenyl]-2-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)pyrimidine (CAS 339101-73-4)
- 7-(Trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxalin-4-one (CAS 1008011-66-2)
Recommended Standards
- 2,3-dichloro-3-[(4-methoxybenzyl)sulfinyl]-N-(6-methoxy-3-pyridinyl)acrylamide (CAS 337922-28-8)
- Carbamic acid, [[[3-chloro-4-(4-chlorophenoxy)phenyl]amino]thioxomethyl]-, 2-methoxyethyl ester (CAS 301352-30-7)
- (2Z)-2,3-Dichloro-N-(6-methoxypyridin-3-yl)-3-[(4-methylphenyl)methanesulfonyl]prop-2-enamide (CAS 1164529-74-1)
- Ethyl 2-[({1-[(2,6-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridin-3-yl}carbamoyl)sulfanyl]acetate (CAS 400084-83-5)
- 3-Fluoro-2-methoxybenzenesulfonyl chloride (CAS 1049729-85-2)
- 6-Nitro-1h-indol-3-yl acetate (CAS 1306604-44-3)
- 3-oxabicyclo[3.1.1]heptan-1-ylmethanol (CAS 2567503-14-2)
- tert-butyl N-[(1S,3R)-3-hydroxycyclohexyl]carbamate (CAS 1638744-25-8)
- 4-(4-Chloro-2-fluorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine (CAS 1158195-73-3)
- Methyl 4,4,4-trifluoro-2-hydroxybutanoate (CAS 1610538-11-8)
- 2-(Isoquinolin-5-yl)propanoic acid (CAS 581813-22-1)
- Methyl 3-(4-methoxyphenoxy)propanoate (CAS 18333-12-5)
- 2-Hydroxy-3-isopropoxy-N,N-dimethylbenzamide (CAS 1243454-68-3)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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