6-(3-Chlorobenzoyl)-2-(2-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydropyridazin-3-one CAS 478043-62-8
| CAS No. | 478043-62-8 |
| Molecular Formula | C18H9Cl2F3N2O2 |
| Molecular Weight | 413.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6-(3-Chlorobenzoyl)-2-(2-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydropyridazin-3-one (CAS 478043-62-8), molecular formula C18H9Cl2F3N2O2 and molecular weight 413.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-(3-Chlorobenzoyl)-2-(2-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydropyridazin-3-one (C18H9Cl2F3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 6-(3-Chlorobenzoyl)-2-(2-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydropyridazin-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H9Cl2F3N2O2 |
| Molecular Weight | 413.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorobenzoyl Standards
- 6-(2-Chlorobenzoyl)-2-(3-chlorophenyl)-5-(trifluoromethyl)pyridazin-3(2H)-one (CAS 478043-63-9)
- 6-(4-Chlorobenzoyl)-2-(2-chlorophenyl)-5-(trifluoromethyl)pyridazin-3(2H)-one (CAS 478043-58-2)
- 6-(4-Chlorobenzoyl)-2-(3-chlorophenyl)-5-(trifluoromethyl)pyridazin-3(2H)-one (CAS 478043-59-3)
- 6-(4-Chlorobenzoyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydropyridazin-3-one (CAS 478043-60-6)
- 2-(4-Chlorobenzoyl)-3-{[(2-chlorophenyl)sulfanyl]methyl}-1-benzofuran (CAS 338424-02-5)
- 2-(4-Chlorobenzoyl)-3-{[(4-chlorophenyl)sulfanyl]methyl}-1-benzofuran (CAS 338411-44-2)
- 1-Benzyl-2-[1-(4-chlorobenzoyl)-1H-pyrazol-3-yl]-1H-1,3-benzodiazole (CAS 477711-18-5)
- 1-(3-Chlorobenzoyl)-4-{[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775471-63-0)
Recommended Standards
- Opicapone (CAS 923287-50-7)
- Opicapone impurity 19 (CAS CATO-C4X-240419)
- Opicapone Impurity 11 (CAS CATO-C4X-240411)
- Pyraflufen-Ethyl (CAS 129630-19-9)
- 3,5-Bis(perfluorohexyl)pyrazole (CAS 1030269-33-0)
- 3-Ethoxy-4-propoxybenzaldehyde (CAS 350988-41-9)
- N-(5-Cyclopropoxy-6-(methylthio)pyridin-2-yl)methanesulfonamide (CAS 1243355-98-7)
- 4-(4-Bromothiophen-2-yl)oxazolidin-2-one (CAS 1378258-79-7)
- 6-Aminopyrimidine-4-carboxylic acid hydrate (CAS 7146-87-4)
- 2-(4-Isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol, 97% (CAS 923289-21-8)
- 1-Allyl-3-methyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione (CAS 39945-20-5)
- 4-Nitrotoluene-d7 (CAS 84344-19-4)
- 3-Chloroimidazo[1,2-a]pyridine-7-carbaldehyde (CAS 1555441-91-2)
- Tau Peptide (273-284) trifluoroacetate salt (CAS 1663490-91-2)
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