6-Cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)pyridine-3-carbonitrile CAS 478049-67-1
| CAS No. | 478049-67-1 |
| Molecular Formula | C14H16F3N3 |
| Molecular Weight | 283.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)pyridine-3-carbonitrile.
6-Cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478049-67-1), molecular formula C14H16F3N3 and molecular weight 283.29 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C14H16F3N3, 6-Cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)pyridine-3-carbonitrile contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 283.29 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16F3N3 |
| Molecular Weight | 283.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
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Recommended Standards
- 5-Amino-3-(tert-butyl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole (CAS 476637-07-7)
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- 4-oxo-4-(4-trifluoromethylphenyl)butyronitrile (CAS 61719-33-3)
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- Methyl (2Z)-2-(benzenesulfonyl)-3-[(4-ethylphenyl)amino]prop-2-enoate (CAS 1327196-59-7)
- Methyl 1-(2-aminothiazol-4-yl)cyclopropane-1-carboxylate (CAS 1996506-66-1)
- (S)-3-amino-4-(m-tolyl)butanoic acid hydrochloride (CAS 331846-93-6)
- 3-Chloro-4-(methylsulfanyl)benzoic acid (CAS 121120-08-9)
- 4-(2-Ethoxypyridin-3-yl)morpholine (CAS 200064-08-0)
- 2-(2-(4-Benzylpiperazin-1-yl)-2-oxoethyl)isoindoline-1,3-dione (CAS 349423-62-7)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
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