6-Cyclopropyl-2-(morpholin-4-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile CAS 478049-66-0
| CAS No. | 478049-66-0 |
| Molecular Formula | C14H14F3N3O |
| Molecular Weight | 297.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-Cyclopropyl-2-(morpholin-4-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478049-66-0) is a high-purity analytical reference standard with the molecular formula C14H14F3N3O and a molecular weight of 297.28 g/mol.
The molecular framework of 6-Cyclopropyl-2-(morpholin-4-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile (C14H14F3N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H14F3N3O |
| Molecular Weight | 297.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
- 6-cyclopropyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-09-3)
- 6-cyclopropyl-1-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011398-69-8)
- 7-Cyclopropyl-2-(2-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5-carboxylic acid (CAS 1226379-36-7)
- N-Cyclopropyl-9-(cyclopropylmethyl)-2-(trifluoromethyl)-9H-purin-6-amine (CAS 195252-47-2)
- 1-[5-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]-1H-imidazole-4-carboxylic acid (CAS 1338660-53-9)
- 1-[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]-1H-imidazole-4-carboxylic acid (CAS 1338665-70-5)
- 6-Cyclopropyl-1-[(5-methylfuran-2-yl)methyl]-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 953905-94-7)
- 5-Cyclopropyl-1-[3-(trifluoromethyl)phenyl]-1h-1,2,3-triazole-4-carboxylic acid (CAS 1017477-72-3)
Recommended Standards
- 5-(4-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 861233-52-5)
- Methyl 1-(2-fluorobenzoyl)-1H-indole-3-carboxylate (CAS 350993-21-4)
- 5-(2-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 677311-06-7)
- Methyl 1-(3-fluorobenzoyl)-1H-indole-3-carboxylate (CAS 332898-29-0)
- 2-chloromethyl-pyrimidine (CAS 54198-88-8)
- 3-(3-Fluoro-4-methylphenyl)propanoic acid (CAS 881189-62-4)
- 1-(2-((3-Methylbenzyl)thio)-4,5-dihydro-1H-imidazol-1-yl)-2-phenoxyethan-1-one (CAS 851803-55-9)
- 1,6-Diacetoxyhexane (CAS 6222-17-9)
- 2-(Benzo[4,5]thiazolo[2,3-c][1,2,4]triazol-3-ylthio)-1-(2-methylpiperidin-1-yl)ethan-1-one (CAS 379238-62-7)
- 4-Amino-3-methyl-1h-pyrazole-1-acetonitrile (CAS 1428776-36-6)
- 3-(4-Hydroxypiperidin-1-yl)azetidine-1-carboxylic acid tert-butyl ester (CAS 178311-46-1)
- 5-Hydroxysulfapyridine (CAS 50930-57-9)
- 1,2,9,10-Tetrachlorodecane CP- (CAS 205646-11-3)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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