6-Methyl-2-(phenylthio)-4-(trifluoromethyl)nicotinonitrile CAS 478049-76-2
| CAS No. | 478049-76-2 |
| Molecular Formula | C14H9F3N2S |
| Molecular Weight | 294.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 6-Methyl-2-(phenylthio)-4-(trifluoromethyl)nicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
6-Methyl-2-(phenylthio)-4-(trifluoromethyl)nicotinonitrile (CAS 478049-76-2) is a high-purity analytical reference standard with the molecular formula C14H9F3N2S and a molecular weight of 294.29 g/mol.
6-Methyl-2-(phenylthio)-4-(trifluoromethyl)nicotinonitrile (C14H9F3N2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H9F3N2S |
| Molecular Weight | 294.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 2-Phenyl-6-((phenylthio)methyl)pyrimidin-4(3H)-one (CAS 339014-42-5)
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- 6-((Phenylthio)methyl)-2-(pyridin-3-yl)pyrimidin-4(3H)-one (CAS 852377-18-5)
- 6-((Phenylthio)methyl)-2-(pyridin-4-yl)pyrimidin-4(3H)-one (CAS 337923-17-8)
- 2-(1-(Phenylthio)cyclopentyl)-2H-benzo[d][1,2,3]triazole (CAS 138883-66-6)
- 1-(1-(Phenylthio)cyclopentyl)-1H-benzo[d][1,2,3]triazole (CAS 138883-73-5)
- 2,6-Bis(phenylthio)pyridine (CAS 247195-66-0)
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Recommended Standards
- 6-(5-(5-Fluoro-6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine (CAS 746667-44-7)
- Ethyl (E)-2-(2-(dimethylamino)vinyl)-4-(trifluoromethyl)thiazole-5-carboxylate (CAS 339026-73-2)
- 5-Amino-2-((3-(trifluoromethyl)phenyl)thio)benzonitrile (CAS 320421-51-0)
- N-(4-methylpyrimidin-2-yl)-4-nitrobenzene-1-sulfonamide (CAS 439928-67-3)
- (6-Chloro-5-(difluoromethyl)-3-methylpyridin-2-yl)methanol (CAS 1805379-01-4)
- 2-(Pyridin-3-yloxy)pyridine-4-carboxylic acid (CAS 1094402-21-7)
- Chlorfenapyr (CAS 122453-73-0)
- 5-Bromo-4-chlorobenzo[c]isothiazole (CAS 2818960-13-1)
- 4-((5-Bromo-4-methoxypyridin-3-yl)sulfonyl)morpholine (CAS 1352499-99-0)
- t-BuDavePhos Pd G3 (CAS 1445085-92-6)
- 2-Methoxyethyl 2-(2-ethoxybenzylidene)-7-methyl-3-oxo-5-(thiophen-2-yl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (CAS 618071-65-1)
- (2-Fluoro-3-methylpyridin-4-yl)methanamine (CAS 1393553-25-7)
- 3-(2-Mercapto-4,4-dimethylpyrimidin-1(4H)-yl)-4-methylbenzoic acid (CAS 1142213-23-7)
- Neuropeptide AF (human) (CAS 192387-38-5)
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