6-Methyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinonitrile CAS 478049-77-3
| CAS No. | 478049-77-3 |
| Molecular Formula | C12H12F3N3 |
| Molecular Weight | 255.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 6-Methyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinonitrile (C12H12F3N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 255.24 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 6-Methyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinonitrile (CAS 478049-77-3), a certified reference material (molecular formula C12H12F3N3, MW 255.24 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-Methyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)nicotinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H12F3N3 |
| Molecular Weight | 255.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Methyl Standards
- (R)-2-(Pyrrolidin-2-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1311255-19-2)
- (S)-2-(pyrrolidin-3-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1370732-56-1)
- (S)-2-(Pyrrolidin-2-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 944030-54-0)
- 4-(Pyrrolidin-1-ylsulfonyl)benzoic acid (CAS 19580-33-7)
- 2-(Pyrrolidin-1-ylsulphonyl)benzoic acid 893615-46-8 KS-00003STJ (CAS 893615-46-8)
- (2-Methyl-6-pyrrolidin-2-yl-pyridin-4-yl)-pyrazin-2-yl-amine (CAS 1361118-52-6)
- (R)-Pyrrolidin-3-yl 2-phenylethanesulfonate (CAS 114715-35-4)
- (S)-Pyrrolidin-3-yl 2-phenylethanesulfonate (CAS 118354-71-5)
Recommended Standards
- 4-(Piperazin-1-yl)-2-(trifluoromethyl)benzonitrile (CAS 262295-57-8)
- 6-Oxo-6-(4-(trifluoromethyl)phenyl)hexanenitrile (CAS 61718-88-5)
- 4-(4-Fluorophenyl)-5-hydroxyisoquinolin-1(2H)-one (CAS 656234-22-9)
- N-(3,5-Difluorophenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide (CAS 724435-68-1)
- 1-{imidazo[1,2-a]pyridin-2-ylmethyl}-1H-pyrazol-3-amine (CAS 1179056-26-8)
- 1-Methyl-N-(3-(trifluoromethyl)phenyl)hydrazine-1-carbothioamide (CAS 70483-65-7)
- (2|A,3|A,4|A,5|A,12R,19|A)-6,7-Didehydro-3,4-dihydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester 3633-92-9 4-Desacetylvindoline Deacetylvindoline Desacetyl Vindoline NSC 91993 (CAS 3633-92-9)
- 2-(1-m-Tolylcyclobutyl)acetic acid (CAS 1439899-07-6)
- 2-Methyl-3-propoxypropane-1-sulfonyl chloride (CAS 1343188-79-3)
- 2-Amino-3-methoxyisonicotinonitrile (CAS 1805560-30-8)
- Nebivolol Impurity 55 (CAS CATO-C4X-196855)
- 2-(Benzylamino)-N-(3,4-dichlorophenyl)acetamide (CAS 380626-09-5)
- 2-Chloro-6-fluorobenzohydrazide (CAS 887267-56-3)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com