N'-[(1Z)-(2-Chloro-4-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide CAS 478063-25-1
| CAS No. | 478063-25-1 |
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
N'-[(1Z)-(2-Chloro-4-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (CAS 478063-25-1), molecular formula C18H13ClFN3O and molecular weight 341.77 g/mol, is a CATO reference standard with documented purity and traceability.
N'-[(1Z)-(2-Chloro-4-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (C18H13ClFN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- N'-[(1E)-(2-Chloro-6-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (CAS 347314-45-8)
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- (S)-2-(4-methoxy-2-methylphenyl)-2-(methylamino)ethan-1-ol (CAS 1213073-97-2)
- 1-(4-fluoro-2-methylphenyl)-1H-pyrazol-3-amine (CAS 1341958-09-5)
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- Indapamide Impurity 29 (CAS CATO-C4X-140029)
- N-(2,5-Dioxopyrrolidin-1-yl)-2-phenylacetamide (CAS 18542-74-0)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
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