Midazolam Impurity 1 CAS 59468-90-5
| CAS No. | 59468-90-5 |
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Midazolam Impurity 1 (CAS 59468-90-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H13ClFN3O and a molecular weight of 341.77 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Midazolam Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 341.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Midazolam Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam EP Impurity D (CAS 59468-83-6)
- Midazolam Impurity 41 (CAS 59468-85-8)
- Midazolam Impurity 32 (CAS CATO-C4X-150932)
- Midazolam Impurity 33 (CAS CATO-C4X-150933)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam Impurity 13 (CAS CATO-C4X-150913)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
Recommended Standards
- N'-[(1Z)-(2-Chloro-4-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (CAS 478063-25-1)
- N'-[(1E)-(2-Chloro-6-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (CAS 347314-45-8)
- 4-Chloro-3-[(2-methoxyphenyl)sulfamoyl]benzoic acid (CAS 325832-92-6)
- 5-Allyl-6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)pyrimidin-4-amine (CAS 1001397-14-3)
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Empagliflozin Impurity 69 (CAS CATO-C4X-106569)
- Irinotecan EP Impurity L HCl (CAS 1992961-26-8)
- 5'-Nitro-[2,3'-bipyridin]-6'(1'H)-one (CAS 62749-36-4)
- Ethyl (3,5-dimethylphenyl)glycinate (CAS 890169-53-6)
- (Quinolin-5-yl)thiourea (CAS 860621-03-0)
- 3’,5’-Bis(trifluoromethyl)propiophenone (CAS 85068-34-4)
- N,1-dimethylcyclohexane-1-carboxamide (CAS 61930-86-7)
- 7-Fluoro-2-(pyridin-3-yl)indoline (CAS 592465-99-1)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com