2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide CAS 478063-77-3
| CAS No. | 478063-77-3 |
| Molecular Formula | C16H11ClF6N2O |
| Molecular Weight | 396.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide (CAS 478063-77-3), molecular formula C16H11ClF6N2O and molecular weight 396.71 g/mol, is a CATO reference standard with documented purity and traceability.
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide (C16H11ClF6N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF6N2O |
| Molecular Weight | 396.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- (S)-2-((4-Chloro-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)pentanedioic acid (CAS 61955-61-1)
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- [(3Z)-5-Chloro-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-3-ylidene]amino acetate (CAS 477864-51-0)
- {3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,2-oxazol-5-yl}(phenyl)methyl acetate (CAS 861211-79-2)
- 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-oxo-1,2-dihydroisoquinoline-4-carboxamide (CAS 339106-89-7)
- N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethyl)-2,6-difluorobenzamide (CAS 1708126-04-8)
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Recommended Standards
- 1,1,3,3,5,5-Hexaethoxy-1,3,5-trisilinane (CAS 17955-67-8)
- Fluopyram (CAS 658066-35-4)
- Stigmasta-3,5-Diene (CAS 4970-37-0)
- Eldecalcitol Impurity 35 (CAS 307953-25-9)
- 7-(Trifluoromethyl)-1H-indazole (CAS 885694-00-8)
- (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl]-2-methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester (CAS 1072449-84-3)
- 1-(2-Amino-5-methylphenyl)-2-(pyrrolidin-1-yl)ethanone (CAS 791015-18-4)
- (S)-2-((S)-2-Acetamidopropanamido)-N-((S)-1-amino-1-oxopropan-2-yl)-3-(1H-indol-3-yl)propanamide (CAS 835650-58-3)
- Gliquidone Impurity 8 (CAS CATO-C4X-30008)
- Atorvastatin Impurity 151 (CAS 737755-14-5)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- 4-[(4-Chlorophenyl)sulfanyl]-6-(methoxymethyl)-2-methylpyrimidine (CAS 338747-85-6)
- tert-Butyl (5-bromooxazol-2-yl)carbamate (CAS 1018833-69-6)
- Human glucagon CRS (CAS 9007-92-5)
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