4-[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]-N-(2,2-dimethoxyethyl)-1H-pyrrole-2-carboxamide CAS 478064-46-9
| CAS No. | 478064-46-9 |
| Molecular Formula | C20H19Cl2N3O5 |
| Molecular Weight | 452.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]-N-(2,2-dimethoxyethyl)-1H-pyrrole-2-carboxamide (CAS 478064-46-9), molecular formula C20H19Cl2N3O5 and molecular weight 452.29 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]-N-(2,2-dimethoxyethyl)-1H-pyrrole-2-carboxamide (C20H19Cl2N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 4-[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]-N-(2,2-dimethoxyethyl)-1H-pyrrole-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19Cl2N3O5 |
| Molecular Weight | 452.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Dichlorophenyl Standards
- 1-[(2,4-Dichlorophenyl)methyl]-2-oxo-N-(4-sulfamoylphenyl)-1,2-dihydropyridine-3-carboxamide (CAS 320419-68-9)
- 2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole (CAS 339277-24-6)
- 2-{[(3,4-dichlorophenyl)methyl]sulfanyl}-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole (CAS 339277-06-4)
- 7-[(E)-2-[(2,4-Dichlorophenyl)methylidene]hydrazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338773-17-4)
- (5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(pyridin-2-ylmethyl)-1H-imidazol-2-yl)methyl carbamate (CAS 178979-84-5)
- 3-({4-[(E)-2-(2,4-dichlorophenyl)ethenyl]pyrimidin-2-yl}sulfanyl)-5-(trifluoromethyl)pyridine-2-carbonitrile (CAS 338968-20-0)
- 5-((2,5-Dichlorophenyl)sulfonyl)-7-(trifluoromethyl)-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoxaline (CAS 861206-83-9)
- 2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoic acid (CAS 315706-13-9)
Recommended Standards
- (E)-2,5-Dioxopyrrolidin-1-yl 17-bromo-4,7,10,13-tetraoxaheptadec-15-en-1-oate (CAS 1283658-84-3)
- 5,7-Dichloro-4-(1,3-diphenylureido)quinoline-2-carboxylic acid (CAS 210692-58-3)
- PIK-75 (CAS 372196-67-3)
- N-{4-[(4-bromophenyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzamide (CAS 339031-27-5)
- 2-Nitro-3-(trifluoromethyl)benzonitrile (CAS 1227572-30-6)
- 5-(3-Hydroxy-3-methyl-azetidine-1-carbonyl)-1h-pyrimidine-2,4-dione (CAS 1467999-93-4)
- 3-chloro-5-iodo-7H-pyrrolo[2,3-c]pyridazine (CAS 2416229-23-5)
- S-Allyl-D-cysteine (CAS 770742-93-3)
- 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malononitrile (CAS 338956-33-5)
- 2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 (CAS 1173019-61-8)
- (3,4-Dichlorophenyl)(thiazol-2-yl)methanone (CAS 1039167-75-3)
- 4-Cyano-N-(4-iodophenyl)benzamide (CAS 448200-86-0)
- Rel-(1r,4r)-4-ethoxycyclohexan-1-amine (CAS 72342-87-1)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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