8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine CAS 478066-06-7
| CAS No. | 478066-06-7 |
| Molecular Formula | C7H3ClF3N3 |
| Molecular Weight | 221.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 478066-06-7), molecular formula C7H3ClF3N3 and molecular weight 221.57 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (C7H3ClF3N3) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 221.57 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF3N3 |
| Molecular Weight | 221.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 7-Chloro-5-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 100478-05-5)
- 4-Chloro-2-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1060815-85-1)
- 4-Chloro-6-(trifluoromethyl)-1,2,3-benzotriazole (CAS 1086836-70-5)
- 6-Chloro-2-(trifluoromethyl)imidazo[1,2-b]pyridazine (CAS 109113-97-5)
- 2-Chloro-5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine (CAS 114087-69-3)
- 3-Chloro-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 1211518-18-1)
- 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1211520-73-8)
- 8-Chloro-5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1260860-23-8)
Recommended Standards
- 8-Chloro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine (CAS 611240-68-7)
- 2-Chloro-2,2-difluoro-N-(2-hydroxyphenyl)acetamide (CAS 1309602-47-8)
- 6-Chloro-2-(trifluoromethyl)-1H-imidazo[4,5-c]pyridine (CAS 2384077-16-9)
- Methyl 3-amino-2-chloro-4,5-difluorobenzoate (CAS 1339551-27-7)
- [6-(piperidin-1-yl)pyridin-3-yl]methanamine (CAS 914637-06-2)
- 2-[(4-Chlorophenyl)methoxy]-N,N-dimethyl-ethanamine (CAS 91428-63-6)
- Methyl (2-(hydroxymethyl)-3-methylphenyl)carbamate (CAS 117550-23-9)
- 2,6-Diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile (CAS 127118-56-3)
- (5-Bromo-3-(difluoromethyl)-2-methoxypyridin-4-yl)methanamine (CAS 1805240-33-8)
- Benzeneacetic acid, 3-amino-2-methyl-, methyl ester (CAS 1261877-85-3)
- 3-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-5-methylcyclohex-2-en-1-one (CAS 1024353-40-9)
- 4,4'-(Thiobis(methylene))bis(2,6-di-tert-butylphenol) (CAS 1620-93-5)
- Methyl (1-Adamantanyl 5-acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-thio-D-glycero-a-D-galacto-non-2-ulopyranoside)onate (CAS 956107-32-7)
- Semaglutide impurity 68 (CAS CATO-C4X-222668)
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