5-[(6-Chloropyridin-3-yl)methylidene]-3-ethyl-2-[(4H-1,2,4-triazol-4-yl)imino]-1,3-thiazolidin-4-one CAS 478078-07-8
| CAS No. | 478078-07-8 |
| Molecular Formula | C13H11ClN6OS |
| Molecular Weight | 334.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-[(6-Chloropyridin-3-yl)methylidene]-3-ethyl-2-[(4H-1,2,4-triazol-4-yl)imino]-1,3-thiazolidin-4-one (CAS 478078-07-8) is a high-purity analytical reference standard with the molecular formula C13H11ClN6OS and a molecular weight of 334.78 g/mol.
The molecular framework of 5-[(6-Chloropyridin-3-yl)methylidene]-3-ethyl-2-[(4H-1,2,4-triazol-4-yl)imino]-1,3-thiazolidin-4-one (C13H11ClN6OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11ClN6OS |
| Molecular Weight | 334.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Chloropyridin Standards
- 1-(2-Chloropyridin-3-yl)-5-(3-(dimethylamino)acryloyl)-3-methylpyrimidine-2,4(1H,3H)-dione (CAS 339279-37-7)
- 2-(2-Chloropyridin-3-yl)-1-(2-methylbenzyl)-1H-benzo[d]imidazole (CAS 338411-54-4)
- 2-(2-Chloropyridin-3-yl)-1-(3-methylbenzyl)-1H-benzo[d]imidazole (CAS 338411-39-5)
- 2-(2-Chloropyridin-3-yl)-1-(4-methylbenzyl)-1H-benzo[d]imidazole (CAS 338411-40-8)
- 2-(6-Chloropyridin-3-yl)-1-(2-methylbenzyl)-1H-benzo[d]imidazole (CAS 339112-69-5)
- 2-(6-Chloropyridin-3-yl)-1-(4-methylbenzyl)-1H-benzo[d]imidazole (CAS 339112-79-7)
- 1-(6-Chloropyridin-2-yl)-4-(1H-1,2,4-triazol-1-yl)-1H-pyrazol-5-yl dimethylcarbamate (CAS 955975-72-1)
- Ethyl 5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylate (CAS 1423030-57-2)
Recommended Standards
- 4-Chloro-N-(3-cyano-4-(methylsulfonyl)phenyl)benzamide (CAS 320421-54-3)
- 6-((4-Chlorophenyl)sulfonyl)quinazoline-2,4-diamine (CAS 51123-82-1)
- 3-Chloro-N-(3-cyano-4-methanesulfonylphenyl)benzamide (CAS 477866-71-0)
- 6-Chloro-1-(phenylsulfonyl)-1H-indole-2-carboxamide (CAS 540740-48-5)
- Tert-butyl10-oxo-3-oxa-7,9-diazabicyclo[3.3.2]decane-7-carboxylate (CAS 1160248-54-3)
- Mono-2-(1-oxoethyl)hexyl Phthalate (CAS 88144-82-5)
- Dimethyl-1,3-thiazole-2-thiol (CAS 5351-51-9)
- 5-Bromo-4-(pyrrolidin-1-yl)pyridine-3-sulfonic acid (CAS 1352541-27-5)
- 3-Iodo-4-(2-methoxyacetamido)benzoic acid (CAS 1131614-49-7)
- N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-methionine Trifluoroacetate Salt (CAS 1217471-51-6)
- N-(2-Hydroxyphenyl)-2-phenylacetamide (CAS 95384-58-0)
- Rifapentine Impurity 12 (CAS CATO-C4X-195912)
- 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 1211651-52-3)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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