1-(3,4-Dichlorobenzyl)-N'-(4-methylbenzoyl)piperidine-4-carbohydrazide CAS 478078-38-5
| CAS No. | 478078-38-5 |
| Molecular Formula | C21H23Cl2N3O2 |
| Molecular Weight | 420.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(3,4-Dichlorobenzyl)-N'-(4-methylbenzoyl)piperidine-4-carbohydrazide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(3,4-Dichlorobenzyl)-N'-(4-methylbenzoyl)piperidine-4-carbohydrazide (CAS 478078-38-5) is a high-purity analytical reference standard with the molecular formula C21H23Cl2N3O2 and a molecular weight of 420.33 g/mol.
1-(3,4-Dichlorobenzyl)-N'-(4-methylbenzoyl)piperidine-4-carbohydrazide (C21H23Cl2N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H23Cl2N3O2 |
| Molecular Weight | 420.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Dichlorobenzyl Standards
- 1-(2-((2,6-Dichlorobenzyl)thio)ethyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid (CAS 306936-26-5)
- N-(1-(2,6-dichlorobenzyl)-2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-3-yl)-3-methylbutanamide (CAS 339025-25-1)
- 2-((2,6-Dichlorobenzyl)thio)-6-methyl-N-(3-nitrophenyl)pyrimidin-4-amine (CAS 333420-81-8)
- 2-(4-((3,4-Dichlorobenzyl)oxy)phenyl)-4-(p-tolyl)pyrimidine (CAS 477846-92-7)
- 2,6-Dichlorobenzyl 1-(2,6-dichlorobenzyl)azetidine-3-carboxylate (CAS 1353959-32-6)
- 4-(2,4-Dichlorobenzyl)-8-(4-nitrophenyl)-1-oxa-4,8-diazaspiro[4.5]Decane (CAS 400075-71-0)
- 1-(3,4-Dichlorobenzyl)-4,6-dimethyl-3-(phenylsulfonyl)pyridin-2(1H)-one (CAS 306977-15-1)
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Recommended Standards
- (4-((1-(2,6-Dichlorophenyl)-4-isopropyl-1H-1,2,3-triazol-5-yl)methoxy)-2,3-dimethylphenyl)methanol (CAS 959800-84-1)
- 2-[3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxamide (CAS 955962-75-1)
- (S)-1,3-bis(4-chlorophenylsulfonyl)pyrrolidine (CAS 1415566-26-5)
- 3-[3,5-Bis(trifluoromethyl)phenyl]-5-(2-methanesulfinylphenyl)-1,2,4-oxadiazole (CAS 339099-89-7)
- 6-Methoxy-7-nitroindoline-2,3-dione (CAS 106976-17-4)
- 5,7-Dichloro-1,2,3,4-tetrahydro-1,6-naphthyridine (CAS 1260666-34-9)
- Benzyl (2R,5R)-2-(hydroxymethyl)-5-propylpyrrolidine-1-carboxylate (CAS 2304457-14-3)
- 4,7-Bis(5-bromothiophen-2-yl)-5,6-difluoro-2-octyl-2H-benzo[d][1,2,3]triazole (CAS 1393528-99-8)
- 1-(3-Methylpiperidin-1-yl)-2-(phenylamino)ethan-1-one (CAS 1181721-24-3)
- 1-Methyl-5-nitro-3-(trifluoromethyl)-1H-pyrazole (CAS 1170473-65-0)
- 2-(Chloromethyl)-4-(2,6-dichlorobenzyl)morpholine (CAS 1197238-24-6)
- 3-(Furo[3,2-b]pyridin-6-yl)prop-2-yn-1-ol (CAS 1228665-83-5)
- Ethyl 4-aminotetrahydro-2H-pyran-4-carboxylate hydrochloride (CAS 255390-15-9)
- Semaglutide impurity 275 (CAS CATO-C4X-2226275)
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