3-Methanesulfonyl-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine CAS 478245-56-6
| CAS No. | 478245-56-6 |
| Molecular Formula | C20H16F3NO3S |
| Molecular Weight | 407.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Methanesulfonyl-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine (CAS 478245-56-6) is a high-purity analytical reference standard with the molecular formula C20H16F3NO3S and a molecular weight of 407.41 g/mol.
The molecular framework of 3-Methanesulfonyl-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine (C20H16F3NO3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H16F3NO3S |
| Molecular Weight | 407.41 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methanesulfonyl Standards
- 1-Boc-3-[2-Methanesulfonyl-5-(3-methylisoxazol-5-yl)pyrimidin-4-yl]piperidine (CAS 1017793-03-1)
- 4-Methanesulfonyl-2-({5-nitro-6-[phenyl(propan-2-yl)amino]pyrimidin-4-yl}amino)butanoic acid (CAS 1025769-91-8)
- 5-Methanesulfonyl-4-[(3-methoxyphenyl)sulfanyl]-2-phenylpyrimidine (CAS 339106-23-9)
- 3-Methanesulfonyl-2-[(4-methoxyphenyl)methanesulfonyl]-4,6-dimethylpyridine (CAS 339016-86-3)
- 3-Methanesulfonyl-2-(2-methoxyphenoxy)-4-methyl-6-phenylpyridine (CAS 478245-50-0)
- Ethyl 4-methanesulfonyl-6-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 866134-46-5)
- 1-Methanesulfonyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine (CAS 1326714-13-9)
- 3-Methanesulfonyl-2-[(4-methoxyphenyl)methanesulfinyl]-4,6-dimethylpyridine (CAS 339016-85-2)
Recommended Standards
- 3-((4-Methoxybenzyl)oxy)-N-(3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 339098-38-3)
- Methyl 5,8-difluoro-4-(piperazin-1-yl-N-BOC protected)quinoline-2-carboxylate (CAS 887267-66-5)
- 2-Nitro-N-(2-(2-(p-tolyl)thiazol-4-yl)ethyl)-4-(trifluoromethyl)aniline (CAS 861207-43-4)
- N-(4-methoxyphenyl)-1-methyl-5-(phenylthio)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 321553-37-1)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(1H-imidazol-1-yl)thiophen-2-yl)boronate (CAS 2223032-27-5)
- ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphoramidate (CAS 6154-31-0)
- 3-(4-Acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-(trifluoromethyl)picolinonitrile (CAS 338758-75-1)
- 1-(4-(Trifluoromethyl)phenyl)pyrrolidin-2-one (CAS 188622-31-3)
- 2-[(2-methoxyphenyl)methyl]azepane (CAS 68841-23-6)
- 4-Methyl-2-pyrrolidin-2-yl-pyrimidine-5-carboxylic acidphenylamide hydrochloride (CAS 1361114-95-5)
- 1-Ethoxy-3-phenyl-1H-pyrrole-2,5-dione (CAS 112025-01-1)
- 1-(2-Methoxyethoxy)-2-nitrobenzene (CAS 62819-95-8)
- 2-((4-(Trifluoromethoxy)phenyl)sulfonamido)benzamide (CAS 562079-34-9)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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