3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-methylphenyl)methylidene]-2-thiophenecarbohydrazide CAS 478246-47-8
| CAS No. | 478246-47-8 |
| Molecular Formula | C20H17FN2O2S |
| Molecular Weight | 368.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-methylphenyl)methylidene]-2-thiophenecarbohydrazide (CAS 478246-47-8), molecular formula C20H17FN2O2S and molecular weight 368.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-methylphenyl)methylidene]-2-thiophenecarbohydrazide (C20H17FN2O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17FN2O2S |
| Molecular Weight | 368.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 1,3-Diethyl 2-{[3-(4-ethylphenoxy)phenyl]methylidene}propanedioate (CAS 866154-79-2)
- 4-[(1E)-3-(4-Methylphenyl)-3-oxoprop-1-en-1-yl]phenyl (2E)-3-phenylprop-2-enoate (CAS 331460-44-7)
- 1-([1,1'-Biphenyl]-4-yl)-3-((4-fluorophenyl)sulfonyl)propan-1-one (CAS 868256-21-7)
- 4-[(2Z)-3-(2,4-Dimethoxyphenyl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate (CAS 307952-82-5)
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