3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-fluorophenyl)methylidene]-2-thiophenecarbohydrazide CAS 478246-48-9
| CAS No. | 478246-48-9 |
| Molecular Formula | C19H14F2N2O2S |
| Molecular Weight | 372.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-fluorophenyl)methylidene]-2-thiophenecarbohydrazide (CAS 478246-48-9), molecular formula C19H14F2N2O2S and molecular weight 372.39 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-fluorophenyl)methylidene]-2-thiophenecarbohydrazide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 372.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-[(4-Fluorobenzyl)oxy]-N-[(E)-(4-fluorophenyl)methylidene]-2-thiophenecarbohydrazide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H14F2N2O2S |
| Molecular Weight | 372.39 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Fluorobenzyl Standards
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- Ethyl 2-((5-((((4-fluorobenzyl)oxy)carbonyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetate (CAS 866042-12-8)
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Recommended Standards
- 2'-Deoxy-5-fluoro-3'-C-octanoyluridine (CAS 86977-19-7)
- 4-Allyl-5-(2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazol-4-yl)-4H-1,2,4-triazole-3-thiol (CAS 956964-73-1)
- 2-(4-Fluorophenoxy)-N-(2-oxo-2-(2-phenylmorpholino)ethyl)acetamide (CAS 953948-82-8)
- Methyl 3-(5-(((4-methoxybenzoyl)oxy)methyl)furan-2-yl)thiophene-2-carboxylate (CAS 320418-01-7)
- 4-Chloro-5-methyl-1,3-dihydro-2,1-benzoxaborol-1-ol (CAS 2121515-09-9)
- Methyl 2-hydroxyacrylate (CAS 44545-99-5)
- 5-Oxo-N-(pyridin-2-ylmethyl)-4-(thiophen-2-ylmethyl)morpholine-3-carboxamide (CAS 1421444-40-7)
- N,N-Diethyloctanamide (CAS 996-97-4)
- (R)-1-(5-bromobenzofuran-2-yl)ethan-1-ol (CAS 600727-05-7)
- N-(3,4-Dimethylphenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775347-65-3)
- N-(3-isopropoxyphenyl)-2-(1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl)benzamide (CAS 680213-73-4)
- 2-(3-Amino-4-hydroxyphenyl)acetohydrazide (CAS 1147979-46-1)
- 2-(2-Amino-1,3-thiazol-4-yl)acetohydrazide (CAS 63788-65-8)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
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