4-Amino-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxyquinazoline-2(3H)-thione CAS 478249-75-1
| CAS No. | 478249-75-1 |
| Molecular Formula | C18H18ClN3O3S |
| Molecular Weight | 391.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Amino-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxyquinazoline-2(3H)-thione is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Amino-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxyquinazoline-2(3H)-thione (CAS 478249-75-1), a certified reference material (molecular formula C18H18ClN3O3S, MW 391.87 g/mol) for analytical method development and quality control.
4-Amino-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxyquinazoline-2(3H)-thione (C18H18ClN3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Amino-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxyquinazoline-2(3H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClN3O3S |
| Molecular Weight | 391.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- Methyl 2-amino-6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (CAS 321430-29-9)
- 3-Amino-N-(3-bromo-4-methoxyphenyl)-4-chlorobenzene-1-sulfonamide (CAS 721908-30-1)
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Recommended Standards
- 4-(4-Chlorophenyl)-3-{2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl}-1,2-oxazole (CAS 478032-54-1)
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- 3-((4-Chlorophenyl)thio)-2-phenylquinoline-4-carboxylic acid (CAS 477867-87-1)
- Methyl 2-(4-chlorophenyl)-3-(4-methoxybenzoyl)thiazolidine-4-carboxylate (CAS 477725-42-1)
- 2,4-Dichloro-6-(2-methoxyphenyl)-1,3,5-triazine (CAS 90723-85-6)
- 6-Hydroxybenzo[d]isothiazole-3-carboxylic acid (CAS 932702-33-5)
- 2-(1,3-dioxan-2-yl)acetic acid (CAS 854841-27-3)
- 2-(3-Propyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)acetic acid (CAS 1017422-92-2)
- 2-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-methylpyrazine (CAS 1432909-94-8)
- 6-[(hydroxyimino)methyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 81450-61-5)
- 4-Fluoro-2-(methylamino)phenol (CAS 1243392-93-9)
- Dexmedetomidine Impurity 46 (CAS CATO-C4X-123046)
- 2-(4-Ethylphenyl)-4-nitroisoindoline-1,3-dione (CAS 89024-44-2)
- Hexapeptide-10 (CAS 146439-94-3)
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