3-(3-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione CAS 478255-15-1
| CAS No. | 478255-15-1 |
| Molecular Formula | C17H15ClN4O2S |
| Molecular Weight | 374.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(3-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(3-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478255-15-1), molecular formula C17H15ClN4O2S and molecular weight 374.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(3-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (C17H15ClN4O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(3-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H15ClN4O2S |
| Molecular Weight | 374.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chlorophenyl Standards
- 1-(2-Chlorophenyl)-3-(2-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)ethyl)urea (CAS 1049225-96-8)
- 2-((5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-1-(4-ethoxyphenyl)ethan-1-one (CAS 538338-01-1)
- 3-(2-Chlorophenyl)-4-((3-ethoxy-2-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478253-81-5)
- 3-(2-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-28-3)
- 3-(3-Chlorophenyl)-4-((3-ethoxy-2-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-62-5)
- 5-(2-Chlorophenyl)-4-((2,4-dimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol (CAS 352329-58-9)
- N-(4-Chlorophenyl)-2-((4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 578736-90-0)
- 2-(2-(4-Chlorophenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-methoxypropyl)acetamide (CAS 941939-21-5)
Recommended Standards
- 3-(4-Chlorobenzyl)-4-oxo-2-(phenylimino)-1,3-thiazinane-6-carboxylic acid (CAS 312512-86-0)
- 3-(5-Chlorothiophen-2-yl)-N'-(2-ethoxybenzylidene)-1H-pyrazole-5-carbohydrazide (CAS 303106-95-8)
- 4-(4-Chloro-2-methylphenoxy)-5-methanesulfonyl-2-phenylpyrimidine (CAS 478080-90-9)
- 2-Chloro-1-(4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)sulfonyl)piperazin-1-yl)ethan-1-one (CAS 877963-90-1)
- 6, 7-dihydroxyisobutylast (CAS 101162-42-9)
- ethyl 5-amino-1-methyl-4H-pyrrolo[3,2-c]pyrazole-6-carboxylate (CAS 2459388-98-6)
- 2-(Methylamino)-9H-fluoren-9-one (CAS 5416-84-2)
- 4-Fluoro-2,2-dimethylpiperidine (CAS 1888804-40-7)
- 6'-Chlorospiro[cyclopropane-1,1'-isoindolin]-3'-one (CAS 1396777-82-4)
- Ethane-1,2-diamine bis((2R,3R)-2,3-dihydroxysuccinate) (CAS 996-78-1)
- SAP-I (CAS 76901-59-2)
- Norepinephrine Impurity 158 (CAS CATO-C4X-1514158)
- 3,4-Dichloro-2-nitrobenzoic acid (CAS 13494-59-2)
- Hippocampal Cholinergic Neurostimulating Peptide (CAS 140158-49-2)
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