Ethyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate CAS 478261-60-8
| CAS No. | 478261-60-8 |
| Molecular Formula | C15H15F2NO3 |
| Molecular Weight | 295.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 478261-60-8) is a high-purity analytical reference standard with the molecular formula C15H15F2NO3 and a molecular weight of 295.28 g/mol.
The molecular framework of Ethyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (C15H15F2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Ethyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H15F2NO3 |
| Molecular Weight | 295.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-3-methylbutanamide (CAS 941922-06-1)
- (2E)-2-[2-(2,4-Difluorophenyl)hydrazin-1-ylidene]-4,4,4-trifluoro-3-oxobutanoic acid (CAS 860785-81-5)
- (5Z)-5-[(3,4-Difluorophenyl)methylidene]-4H,5H,6H-thieno[2,3-b]thiopyran-4-one (CAS 1164519-74-7)
- 1-(3,4-Difluorophenyl)-4-ethoxy-6-oxo-1,6-dihydropyridazine-3-carboxylic acid (CAS 1638612-69-7)
- Methyl 1-(3,4-difluorophenyl)-4-methoxy-6-oxo-1,6-dihydropyridazine-3-carboxylate (CAS 1708401-72-2)
- 1-(2,4-Difluorophenyl)-3-(piperidin-1-yl)pyrrolidine-2,5-dione (CAS 306730-21-2)
- (3E)-3-[(2,4-Difluorophenyl)imino]-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indol-2-one (CAS 478031-70-8)
- 1-(2,4-Difluorophenyl)-3-morpholinopyrrolidine-2,5-dione (CAS 676160-52-4)
Recommended Standards
- 5-Phenyl-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine (CAS 850021-29-3)
- Posaconazole Impurity 123 (CAS 149882-18-8)
- 4-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenol (CAS 880088-31-3)
- Posaconazole impurity 235 (CAS CATO-C4X-1208235)
- N-(2-Ethoxyphenyl)-3-oxobutanamide (CAS 41687-09-6)
- N-(3,4-Dimethoxyphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine (CAS 380437-07-0)
- N-Benzyl-2-chloro-N-(2-chloroethyl)ethan-1-amine (CAS 55-51-6)
- methyl 3-amino-2-[(3,4,5-trifluorophenyl)methyl]propanoate hydrochloride (CAS 1788564-75-9)
- 2-Methoxy-6-propan-2-ylpyridine-3-carboxylic acid (CAS 1256786-15-8)
- 1-Fluoro-2,4,5-trimethylbenzene (CAS 400-01-1)
- 2-Amino-2-phenylethanethioamide (CAS 16256-21-6)
- (E)-[(2,4-Dichlorophenyl)methoxy]({2-[(2,4-dichlorophenyl)sulfanyl]pyridin-3-yl}methylidene)amine (CAS 478031-13-9)
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (CAS 20335-68-6)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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