Posaconazole Impurity 123 CAS 149882-18-8
| CAS No. | 149882-18-8 |
| Molecular Formula | C14H15F2N3O2 |
| Molecular Weight | 295.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Posaconazole Impurity 123 (C14H15F2N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Posaconazole Impurity 123 (CAS 149882-18-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15F2N3O2 and a molecular weight of 295.28 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15F2N3O2 |
| Molecular Weight | 295.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Posaconazole Standards
- Posaconazole impurity 235 (CAS CATO-C4X-1208235)
- Posaconazole Impurity 55 (CAS CATO-C4X-120855)
- Posaconazole Impurity 57 (CAS 160709-02-4)
- Posaconazole impurity 253 (CAS CATO-C4X-1208253)
- Posaconazole Impurity 104 (CAS CATO-C4X-1208104)
- Posaconazole Impurity 106 (CAS 192448-07-0)
- Posaconazole impurity 226 (CAS CATO-C4X-1208226)
- Posaconazole Impurity 111 (CAS 112559-81-6)
Recommended Standards
- Ethyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 478261-60-8)
- 5-Phenyl-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine (CAS 850021-29-3)
- 4-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenol (CAS 880088-31-3)
- 4-(Prop-2-yn-1-ylsulfanyl)-2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidine (CAS 338418-25-0)
- Vilanterol Impurity 83 (CAS CATO-C4X-193583)
- All-rac-alfa-Tocopherol EP Impurity B (Mixture of Diastereomers) (CAS CATO-C4X-119515)
- Cefdinir Impurity 58 (CAS CATO-C4X-121058)
- (5-(3-Methoxyphenyl)isoxazol-3-yl)methanamine hydrochloride (CAS 1263094-48-9)
- (S)-4-(tert-butoxy)-4-oxo-2-((R)-1-phenylethyl)butanoic acid (CAS 1229381-11-6)
- 4-(2-Chlorophenyl)butan-2-one (CAS 3506-72-7)
- 3-{[(9H-fluoren-9-ylmethoxy)carbonyl](2-methylpropyl)amino}propanoic acid (CAS 1393817-23-6)
- 1-(4-Bromo-2-methoxyphenyl)-2-methoxyethan-1-one (CAS 1602797-71-6)
- Sarpogrelate Impurity 3 (CAS 135963-42-7)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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