(E)-4-methoxy-N-((methoxyimino)methyl)-2-(3-(trifluoromethyl)phenoxy)nicotinamide CAS 478262-38-3
| CAS No. | 478262-38-3 |
| Molecular Formula | C16H14F3N3O4 |
| Molecular Weight | 369.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-4-methoxy-N-((methoxyimino)methyl)-2-(3-(trifluoromethyl)phenoxy)nicotinamide (CAS 478262-38-3), molecular formula C16H14F3N3O4 and molecular weight 369.30 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-4-methoxy-N-((methoxyimino)methyl)-2-(3-(trifluoromethyl)phenoxy)nicotinamide (C16H14F3N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14F3N3O4 |
| Molecular Weight | 369.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- tert-Butyl 4-(1-(3-bromophenyl)ethyl)piperazine-1-carboxylate (CAS 1704082-61-0)
- 1,1,1-Trifluoro-3-(piperidin-1-yl)propan-2-yl 3-(trifluoromethyl)benzoate (CAS 477848-36-5)
- tert-Butyl 4-(1-(4-bromophenyl)ethyl)piperazine-1-carboxylate (CAS 1704069-46-4)
- N-((S)-1-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (CAS 2641466-98-8)
- 2-((4-Methoxybenzyl)oxy)benzaldehyde (CAS 209120-28-5)
- 6-(3-Chloropropyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1935123-63-9)
- Methyl 8-methylquinoline-7-carboxylate (CAS 1030846-94-6)
- Tizanidine impurity 29 (CAS CATO-C4X-144529)
- 1-(3-Chlorobutyl)pyrrolidine (CAS 35929-24-9)
- Chlorpromazine N-Oxide Maleic Acid Salt (CAS 18683-80-2)
- Ribavirin Impurity S (CAS 79-17-4)
- 7-Amino-2-methyl-1h,5h-pyrazolo[1,5-a]pyrimidin-5-one (CAS 96335-50-1)
- 3-Methoxy-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (CAS 1375108-20-5)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
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