Citalopram EP Impurity F HBr CAS 479065-02-6
| CAS No. | 479065-02-6 |
| Molecular Formula | C19H21BrFNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Citalopram EP Impurity F HBr (CAS 479065-02-6, C19H21BrFNOHBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Citalopram EP Impurity F HBr is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 459.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21BrFNO HBr |
| Molecular Weight | 459.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Citalopram Standards
- Citalopram Impurity 38 (CAS 103146-26-5)
- Citalopram Impurity 17 (CAS 1187671-15-3)
- Citalopram EP Impurity D HBr (CAS 1188264-72-3)
- Citalopram-d6 N-Oxide (CAS 1189652-54-7)
- Citalopram-d6 (CAS 1190003-26-9)
- (R)-Citalopram-d6 N-Oxide (CAS 1217669-62-9)
- (S)-Citalopram-d6 N-Oxide (CAS 1217710-65-0)
- (S)-Citalopram-d6 Oxalate (CAS 1217733-09-9)
Recommended Standards
- Finerenone Impurity 190 (CAS CATO-C4X-2880190)
- Lacosamide Impurity C59 (CAS 1466-67-7)
- Levofloxacin Impurity 87 (CAS CATO-C4X-137187)
- 2-((5-(4-Chlorophenyl)oxazol-2-yl)thio)-1-(piperidin-1-yl)ethan-1-one (CAS 1021228-39-6)
- 2-(Isochroman-7-yl)acetic acid (CAS 1028666-38-7)
- Brivaracetam Impurity 158 (CAS 855209-27-7)
- 5-Benzyl-1h-pyrrole-2-carboxylic acid (CAS 175210-38-5)
- 5-(4-(Methylsulfonyl)piperazin-1-yl)pyridin-2-amine, 97% (CAS 1156511-30-6)
- N-(2-Phenoxyethyl)-4-phenylbutanamide (CAS 1105208-70-5)
- Semaglutide impurity 106 (CAS CATO-C4X-2226106)
Why CATO?
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