4-(3,4-Difluorophenoxy)benzaldehyde CAS 486449-90-5
| CAS No. | 486449-90-5 |
| Molecular Formula | C13H8F2O2 |
| Molecular Weight | 234.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(3,4-Difluorophenoxy)benzaldehyde.
4-(3,4-Difluorophenoxy)benzaldehyde (CAS 486449-90-5), molecular formula C13H8F2O2 and molecular weight 234.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(3,4-Difluorophenoxy)benzaldehyde (C13H8F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8F2O2 |
| Molecular Weight | 234.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Difluorophenoxy Standards
- 2-(2,4-Difluorophenoxy)benzaldehyde, 97% (CAS 902836-94-6)
- 2-(3,4-Difluorophenoxy)benzaldehyde (CAS 289717-89-1)
- 2-(3,5-Difluorophenoxy)benzaldehyde (CAS 886361-01-9)
- 4-(3,5-Difluorophenoxy)benzaldehyde (CAS 959235-83-7)
- 2-(2,4-Difluorophenoxy)butanoyl chloride (CAS 1160257-44-2)
- 2-(2,4-Difluorophenoxy)-2-methylpropanoyl chloride (CAS 936327-47-8)
- 2-(2,4-Difluorophenoxy)-5-methylaniline (CAS 183110-82-9)
- 2-(2,4-Difluorophenoxy)-4-methylaniline (CAS 946774-65-8)
Recommended Standards
- 4-(2-Fluorophenyl)-2-fluorobenzoic acid (CAS 505082-83-7)
- 4-(2,6-Difluorophenyl)benzoic acid (CAS 505082-79-1)
- 4-(Fluorosulfonyl)-3-methoxybenzoic acid (CAS 935534-26-2)
- 4-(2,5-Difluorophenyl)benzoic acid (CAS 920294-24-2)
- N1-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-4-(trifluoromethyl)benzene-1,2-diamine (CAS 478262-14-5)
- Methyl 5-Bromo-2-formylbenzoate (CAS 1016163-89-5)
- 2-(1-Benzofuran-4-yl)acetonitrile (CAS 84549-02-0)
- 1-(Methylamino)-3-phenoxypropan-2-ol (CAS 39631-73-7)
- Ethyl 1-benzyl-4-(2-fluorophenyl)pyrrolidine-3-carboxylate (CAS 874990-49-5)
- 2,3',4',5'-Tetrafluoro-[1,1'-biphenyl]-4-ol (CAS 335125-98-9)
- Paederosidic Acid (CAS 18842-98-3)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (CAS 1073354-61-6)
- Niacin acyl-β-D-glucuronide (CAS 24719-73-1)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
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