4-(4-Chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one CAS 488804-17-7
| CAS No. | 488804-17-7 |
| Molecular Formula | C22H19ClN2O6 |
| Molecular Weight | 442.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one.
4-(4-Chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one (CAS 488804-17-7), molecular formula C22H19ClN2O6 and molecular weight 442.85 g/mol, is a CATO reference standard with documented purity and traceability.
4-(4-Chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one (C22H19ClN2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19ClN2O6 |
| Molecular Weight | 442.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorobenzoyl Standards
- Ethyl 4-(4-chlorobenzoyl)-8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate (CAS 1030920-60-5)
- 2-(4-Chlorobenzoyl)-3-[(2-chlorobenzenesulfonyl)methyl]-1-benzofuran (CAS 400077-41-0)
- 2-(4-Chlorobenzoyl)-3-[(4-chlorobenzenesulfonyl)methyl]-1-benzofuran (CAS 338411-59-9)
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- 2-(4-Chlorobenzoyl)-3-({[3-(trifluoromethyl)phenyl]sulfanyl}methyl)-1-benzofuran (CAS 338411-49-7)
Recommended Standards
- (4-(2-Chloro-4-nitrophenyl)piperazin-1-yl)(3-(4-hydroxyphenyl)-5-methylisoxazol-4-yl)methanone (CAS 1264870-21-4)
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- N-benzyl-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonamide (CAS 344278-17-7)
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- 3-(n-Ethyl-2,2,2-trifluoroacetamido)-2-methylpropanoic acid (CAS 1342271-55-9)
- 1-(2-Methoxyphenoxy)propan-2-one oxime (CAS 6437-45-2)
- tert-Butyl2-(4-fluorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (CAS 1773507-35-9)
- 2-(Carboxymethylthio)-Ethyl Ether (CAS 4408-66-6)
- tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate (CAS 1312712-22-3)
- 3-Amino-1-cyclopropylurea (CAS 1094561-77-9)
- 4-Methyl-4-nitro-1-(thiophen-2-yl)pentan-1-one (CAS 400085-20-3)
- 2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)ethanol (CAS 2703918-42-5)
- 1-(1,3-Dimethyl-1H-pyrazol-4-yl)-2-mercapto-4-((1-methyl-1H-pyrazol-4-yl)methylene)-1H-imidazol-5(4H)-one (CAS 1005626-64-1)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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