5-Fluorobenzo[d][1,3]dioxole-4-carboxylic acid CAS 492444-08-3
| CAS No. | 492444-08-3 |
| Molecular Formula | C8H5FO4 |
| Molecular Weight | 184.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
5-Fluorobenzo[d][1,3]dioxole-4-carboxylic acid (CAS 492444-08-3), molecular formula C8H5FO4 and molecular weight 184.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Fluorobenzo[d][1,3]dioxole-4-carboxylic acid (C8H5FO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5FO4 |
| Molecular Weight | 184.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Fluorobenzo Standards
- (7-Fluorobenzo[d][1,3]dioxol-4-yl)boronic acid (CAS 1256345-92-2)
- (4-Fluorobenzo[d][1,3]dioxol-5-yl)boronic acid (CAS 943830-75-9)
- (4-Fluorobenzo[d]thiazol-2-yl)methanol (CAS 1188025-81-1)
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